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Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.

dc.contributor.author Deng, ZD
dc.contributor.author Egner, Tobias
dc.contributor.author Grigsby, EM
dc.contributor.author Grill, WM
dc.contributor.author Mueller, JK
dc.contributor.author Peterchev, A
dc.contributor.author Petraglia, FW
dc.contributor.author Platt, ML
dc.contributor.author Prevosto, V
dc.contributor.author Rao, Hrishikesh
dc.contributor.author Sommer, Marc A
dc.coverage.spatial United States
dc.date.accessioned 2015-02-16T04:18:11Z
dc.date.issued 2014-08
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/24974797
dc.identifier nn.3751
dc.identifier.uri https://hdl.handle.net/10161/9482
dc.description.abstract Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report new methods for studying the influence of TMS on single neurons in the brain of alert non-human primates. We designed a TMS coil that focuses its effect near the tip of a recording electrode and recording electronics that enable direct acquisition of neuronal signals at the site of peak stimulus strength minimally perturbed by stimulation artifact in awake monkeys (Macaca mulatta). We recorded action potentials within ∼1 ms after 0.4-ms TMS pulses and observed changes in activity that differed significantly for active stimulation as compared with sham stimulation. This methodology is compatible with standard equipment in primate laboratories, allowing easy implementation. Application of these tools will facilitate the refinement of next generation TMS devices, experiments and treatment protocols.
dc.language eng
dc.relation.ispartof Nat Neurosci
dc.relation.isversionof 10.1038/nn.3751
dc.subject Action Potentials
dc.subject Animals
dc.subject Artifacts
dc.subject Electrodes
dc.subject Equipment Design
dc.subject Female
dc.subject Macaca mulatta
dc.subject Male
dc.subject Neurons
dc.subject Patch-Clamp Techniques
dc.subject Prefrontal Cortex
dc.subject Transcranial Magnetic Stimulation
dc.title Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/24974797
pubs.begin-page 1130
pubs.end-page 1136
pubs.issue 8
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Center for Cognitive Neuroscience
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Duke Science & Society
pubs.organisational-group Duke-UNC Center for Brain Imaging and Analysis
pubs.organisational-group Electrical and Computer Engineering
pubs.organisational-group Initiatives
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group Neurosurgery
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Psychiatry & Behavioral Sciences
pubs.organisational-group Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology
pubs.organisational-group Psychology and Neuroscience
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 17
dc.identifier.eissn 1546-1726


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