Impact of coverage-dependent marginal costs on optimal HPV vaccination strategies.
Repository Usage Stats
The effectiveness of vaccinating males against the human papillomavirus (HPV) remains a controversial subject. Many existing studies conclude that increasing female coverage is more effective than diverting resources into male vaccination. Recently, several empirical studies on HPV immunization have been published, providing evidence of the fact that marginal vaccination costs increase with coverage. In this study, we use a stochastic agent-based modeling framework to revisit the male vaccination debate in light of these new findings. Within this framework, we assess the impact of coverage-dependent marginal costs of vaccine distribution on optimal immunization strategies against HPV. Focusing on the two scenarios of ongoing and new vaccination programs, we analyze different resource allocation policies and their effects on overall disease burden. Our results suggest that if the costs associated with vaccinating males are relatively close to those associated with vaccinating females, then coverage-dependent, increasing marginal costs may favor vaccination strategies that entail immunization of both genders. In particular, this study emphasizes the necessity for further empirical research on the nature of coverage-dependent vaccination costs.
SubjectHuman papillomavirus vaccination
Male HPV vaccination
Marginal distribution costs
Optimal vaccine distribution
Stochastic agent-based models
Health Care Rationing
Human papillomavirus 16
Published Version (Please cite this version)10.1016/j.epidem.2015.01.003
Publication InfoRyser, MD; McGoff, K; Herzog, DP; Sivakoff, DJ; & Myers, ER (2015). Impact of coverage-dependent marginal costs on optimal HPV vaccination strategies. Epidemics, 11. pp. 32-47. 10.1016/j.epidem.2015.01.003. Retrieved from https://hdl.handle.net/10161/9500.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
More InfoShow full item record
Evan Robert Myers
Walter L. Thomas Distinguished Professor of Obstetrics and Gynecology in the School of Medicine
My research interests are broadly in the application of quantitative methods, especially mathematical modeling and decision analysis, to problems in women's health. Recent and current activities include integration of simulation modeling and systematic reviews to inform decisions surrounding cervical, ovarian, and breast cancer prevention and control, screening for postpartum depression, and management of uterine fibroids. We are also engaged in exploring methods for integrating gui
Marc Daniel Ryser
Assistant Professor in Population Health Sciences
Marc D. Ryser conducts research in cancer early detection, with a particular focus on breast cancer overdiagnosis and overtreatment. Using a multi-scale approach, his group generates and analyzes biologic, clinical and population data using a variety of mathematical, statistical and computational tools. Examples of ongoing projects include the evolutionary dynamics of early-stage breast cancer; decision support tools for early-stage breast cancer patients; and estimation of breast can
Alphabetical list of authors with Scholars@Duke profiles.
Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info
Showing items related by title, author, creator, and subject.
Potent functional antibody responses elicited by HIV-I DNA priming and boosting with heterologous HIV-1 recombinant MVA in healthy Tanzanian adults. Joachim, Agricola; Nilsson, Charlotta; Aboud, Said; Bakari, Muhammad; Lyamuya, Eligius F; Robb, Merlin L; Marovich, Mary A; ... (16 authors) (PLoS One, 2015)UNLABELLED: Vaccine-induced HIV antibodies were evaluated in serum samples collected from healthy Tanzanian volunteers participating in a phase I/II placebo-controlled double blind trial using multi-clade, multigene HIV-DNA ...
Human Papillomavirus Awareness in Haiti: Preparing for a National HPV Vaccination Program. Boggan, J; Gichane, MW; Calo, WM; McCarthy, SH; Walmer, KA; Brewer, NT (J Pediatr Adolesc Gynecol, 2017-02)STUDY OBJECTIVE: Cervical cancer morbidity and mortality are pressing public health issues that affect women in Haiti. To inform efforts to develop a human papillomavirus (HPV) vaccination program in Haiti, we sought to ...