Impact of coverage-dependent marginal costs on optimal HPV vaccination strategies.
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The effectiveness of vaccinating males against the human papillomavirus (HPV) remains a controversial subject. Many existing studies conclude that increasing female coverage is more effective than diverting resources into male vaccination. Recently, several empirical studies on HPV immunization have been published, providing evidence of the fact that marginal vaccination costs increase with coverage. In this study, we use a stochastic agent-based modeling framework to revisit the male vaccination debate in light of these new findings. Within this framework, we assess the impact of coverage-dependent marginal costs of vaccine distribution on optimal immunization strategies against HPV. Focusing on the two scenarios of ongoing and new vaccination programs, we analyze different resource allocation policies and their effects on overall disease burden. Our results suggest that if the costs associated with vaccinating males are relatively close to those associated with vaccinating females, then coverage-dependent, increasing marginal costs may favor vaccination strategies that entail immunization of both genders. In particular, this study emphasizes the necessity for further empirical research on the nature of coverage-dependent vaccination costs.
SubjectHuman papillomavirus vaccination
Male HPV vaccination
Marginal distribution costs
Optimal vaccine distribution
Stochastic agent-based models
Health Care Rationing
Human papillomavirus 16
Published Version (Please cite this version)10.1016/j.epidem.2015.01.003
Publication InfoHerzog, David P; McGoff, Kevin; Myers, ER; Ryser, MD; & Sivakoff, DJ (2015). Impact of coverage-dependent marginal costs on optimal HPV vaccination strategies. Epidemics, 11. pp. 32-47. 10.1016/j.epidem.2015.01.003. Retrieved from http://hdl.handle.net/10161/9500.
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Visiting Assistant Professor in the Department of Mathematics
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
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