A dimensionless number for understanding the evolutionary dynamics of antigenically variable RNA viruses.

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2011-12-22

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Abstract

Antigenically variable RNA viruses are significant contributors to the burden of infectious disease worldwide. One reason for their ubiquity is their ability to escape herd immunity through rapid antigenic evolution and thereby to reinfect previously infected hosts. However, the ways in which these viruses evolve antigenically are highly diverse. Some have only limited diversity in the long-run, with every emergence of a new antigenic variant coupled with a replacement of the older variant. Other viruses rapidly accumulate antigenic diversity over time. Others still exhibit dynamics that can be considered evolutionary intermediates between these two extremes. Here, we present a theoretical framework that aims to understand these differences in evolutionary patterns by considering a virus's epidemiological dynamics in a given host population. Our framework, based on a dimensionless number, probabilistically anticipates patterns of viral antigenic diversification and thereby quantifies a virus's evolutionary potential. It is therefore similar in spirit to the basic reproduction number, the well-known dimensionless number which quantifies a pathogen's reproductive potential. We further outline how our theoretical framework can be applied to empirical viral systems, using influenza A/H3N2 as a case study. We end with predictions of our framework and work that remains to be done to further integrate viral evolutionary dynamics with disease ecology.

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10.1098/rspb.2011.0435

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Koelle, Katia, Oliver Ratmann, David A Rasmussen, Virginia Pasour and Jonathan Mattingly (2011). A dimensionless number for understanding the evolutionary dynamics of antigenically variable RNA viruses. Proc Biol Sci, 278(1725). pp. 3723–3730. 10.1098/rspb.2011.0435 Retrieved from https://hdl.handle.net/10161/9525.

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Mattingly

Jonathan Christopher Mattingly

Kimberly J. Jenkins Distinguished University Professor of New Technologies

Jonathan Christopher  Mattingly grew up in Charlotte, NC where he attended Irwin Ave elementary and Charlotte Country Day.  He graduated from the NC School of Science and Mathematics and received a BS is Applied Mathematics with a concentration in physics from Yale University. After two years abroad with a year spent at ENS Lyon studying nonlinear and statistical physics on a Rotary Fellowship, he returned to the US to attend Princeton University where he obtained a PhD in Applied and Computational Mathematics in 1998. After 4 years as a Szego assistant professor at Stanford University and a year as a member of the IAS in Princeton, he moved to Duke in 2003. He is currently a Professor of Mathematics and of Statistical Science.

His expertise is in the longtime behavior of stochastic system including randomly forced fluid dynamics, turbulence, stochastic algorithms used in molecular dynamics and Bayesian sampling, and stochasticity in biochemical networks.

Since 2013 he has also been working to understand and quantify gerrymandering and its interaction of a region's geopolitical landscape. This has lead him to testify in a number of court cases including in North Carolina, which led to the NC congressional and both NC legislative maps being deemed unconstitutional and replaced for the 2020 elections. 

He is the recipient of a Sloan Fellowship and a PECASE CAREER award.  He is also a fellow of the IMS and the AMS. He was awarded the Defender of Freedom award by  Common Cause for his work on Quantifying Gerrymandering.



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