Age-related effects on the neural correlates of autobiographical memory retrieval.
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Older adults recall less episodically rich autobiographical memories (AM), however, the neural basis of this effect is not clear. Using functional MRI, we examined the effects of age during search and elaboration phases of AM retrieval. Our results suggest that the age-related attenuation in the episodic richness of AMs is associated with difficulty in the strategic retrieval processes underlying recovery of information during elaboration. First, age effects on AM activity were more pronounced during elaboration than search, with older adults showing less sustained recruitment of the hippocampus and ventrolateral prefrontal cortex (VLPFC) for less episodically rich AMs. Second, there was an age-related reduction in the modulation of top-down coupling of the VLPFC on the hippocampus for episodically rich AMs. In sum, the present study shows that changes in the sustained response and coupling of the hippocampus and prefrontal cortex (PFC) underlie age-related reductions in episodic richness of the personal past.
Magnetic Resonance Imaging
Published Version (Please cite this version)10.1016/j.neurobiolaging.2010.11.007
Publication InfoSt Jacques, Peggy L; Rubin, David C; & Cabeza, Roberto (2012). Age-related effects on the neural correlates of autobiographical memory retrieval. Neurobiol Aging, 33(7). pp. 1298-1310. 10.1016/j.neurobiolaging.2010.11.007. Retrieved from https://hdl.handle.net/10161/9768.
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Professor of Psychology and Neuroscience
My laboratory investigates the neural correlates of memory and cognition in young and older adults using fMRI. We have three main lines of research: First, we distinguish the neural correlates of various episodic memory processes. For example, we have compared encoding vs. retrieval, item vs. source memory, recall vs. recognition, true vs. false memory, and emotional vs. nonemotional memory. We are particularly interested in the contribution of prefrontal cortex (PFC) and medial temporal lobe (M
Juanita M. Kreps Distinguished Professor of Psychology and Neuroscience
For .pdfs of all publications click here My main research interest has been in long-term memory, especially for complex (or "real-world") stimuli. This work includes the study of autobiographical memory
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