Age-related effects on the neural correlates of autobiographical memory retrieval.
Abstract
Older adults recall less episodically rich autobiographical memories (AM), however,
the neural basis of this effect is not clear. Using functional MRI, we examined the
effects of age during search and elaboration phases of AM retrieval. Our results suggest
that the age-related attenuation in the episodic richness of AMs is associated with
difficulty in the strategic retrieval processes underlying recovery of information
during elaboration. First, age effects on AM activity were more pronounced during
elaboration than search, with older adults showing less sustained recruitment of the
hippocampus and ventrolateral prefrontal cortex (VLPFC) for less episodically rich
AMs. Second, there was an age-related reduction in the modulation of top-down coupling
of the VLPFC on the hippocampus for episodically rich AMs. In sum, the present study
shows that changes in the sustained response and coupling of the hippocampus and prefrontal
cortex (PFC) underlie age-related reductions in episodic richness of the personal
past.
Type
Journal articleSubject
Acoustic StimulationAdolescent
Adult
Aged
Aging
Female
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Memory, Episodic
Mental Recall
Middle Aged
Prefrontal Cortex
Reaction Time
Young Adult
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https://hdl.handle.net/10161/9768Published Version (Please cite this version)
10.1016/j.neurobiolaging.2010.11.007Publication Info
St Jacques, Peggy L; Rubin, David C; & Cabeza, Roberto (2012). Age-related effects on the neural correlates of autobiographical memory retrieval.
Neurobiol Aging, 33(7). pp. 1298-1310. 10.1016/j.neurobiolaging.2010.11.007. Retrieved from https://hdl.handle.net/10161/9768.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Roberto Cabeza
Professor of Psychology and Neuroscience
My laboratory investigates the neural correlates of memory and cognition in young
and older adults using fMRI. We have three main lines of research: First, we distinguish
the neural correlates of various episodic memory processes. For example, we have compared
encoding vs. retrieval, item vs. source memory, recall vs. recognition, true vs. false
memory, and emotional vs. nonemotional memory. We are particularly interested in the
contribution of prefrontal cortex (PFC) and medial temporal lobe (M
David C. Rubin
Juanita M. Kreps Distinguished Professor of Psychology and Neuroscience
For .pdfs of all publications click here My main research interest has been in long-term
memory, especially for complex (or "real-world") stimuli. This work includes the study
of autobiographical memory and oral traditions, as w
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