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Age-related effects on the neural correlates of autobiographical memory retrieval.

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Date
2012-07
Authors
St Jacques, Peggy L
Rubin, David C
Cabeza, Roberto
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Abstract
Older adults recall less episodically rich autobiographical memories (AM), however, the neural basis of this effect is not clear. Using functional MRI, we examined the effects of age during search and elaboration phases of AM retrieval. Our results suggest that the age-related attenuation in the episodic richness of AMs is associated with difficulty in the strategic retrieval processes underlying recovery of information during elaboration. First, age effects on AM activity were more pronounced during elaboration than search, with older adults showing less sustained recruitment of the hippocampus and ventrolateral prefrontal cortex (VLPFC) for less episodically rich AMs. Second, there was an age-related reduction in the modulation of top-down coupling of the VLPFC on the hippocampus for episodically rich AMs. In sum, the present study shows that changes in the sustained response and coupling of the hippocampus and prefrontal cortex (PFC) underlie age-related reductions in episodic richness of the personal past.
Type
Journal article
Subject
Acoustic Stimulation
Adolescent
Adult
Aged
Aging
Female
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Memory, Episodic
Mental Recall
Middle Aged
Prefrontal Cortex
Reaction Time
Young Adult
Permalink
https://hdl.handle.net/10161/9768
Published Version (Please cite this version)
10.1016/j.neurobiolaging.2010.11.007
Publication Info
St Jacques, Peggy L; Rubin, David C; & Cabeza, Roberto (2012). Age-related effects on the neural correlates of autobiographical memory retrieval. Neurobiol Aging, 33(7). pp. 1298-1310. 10.1016/j.neurobiolaging.2010.11.007. Retrieved from https://hdl.handle.net/10161/9768.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Cabeza

Roberto Cabeza

Professor of Psychology and Neuroscience
My laboratory investigates the neural correlates of memory and cognition in young and older adults using fMRI. We have three main lines of research: First, we distinguish the neural correlates of various episodic memory processes. For example, we have compared encoding vs. retrieval, item vs. source memory, recall vs. recognition, true vs. false memory, and emotional vs. nonemotional memory. We are particularly interested in the contribution of prefrontal cortex (PFC) and medial temporal lobe (M
Rubin

David C. Rubin

Juanita M. Kreps Distinguished Professor of Psychology and Neuroscience
For .pdfs of all publications click here  My main research interest has been in long-term memory, especially for complex (or "real-world") stimuli. This work includes the study of autobiographical memory and oral traditions, as w
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