Show simple item record

Age-related effects on the neural correlates of autobiographical memory retrieval.

dc.contributor.author Cabeza, Roberto
dc.contributor.author Rubin, David C
dc.contributor.author St Jacques, PL
dc.coverage.spatial United States
dc.date.accessioned 2015-05-12T14:31:26Z
dc.date.issued 2012-07
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/21190759
dc.identifier S0197-4580(10)00488-4
dc.identifier.uri https://hdl.handle.net/10161/9768
dc.description.abstract Older adults recall less episodically rich autobiographical memories (AM), however, the neural basis of this effect is not clear. Using functional MRI, we examined the effects of age during search and elaboration phases of AM retrieval. Our results suggest that the age-related attenuation in the episodic richness of AMs is associated with difficulty in the strategic retrieval processes underlying recovery of information during elaboration. First, age effects on AM activity were more pronounced during elaboration than search, with older adults showing less sustained recruitment of the hippocampus and ventrolateral prefrontal cortex (VLPFC) for less episodically rich AMs. Second, there was an age-related reduction in the modulation of top-down coupling of the VLPFC on the hippocampus for episodically rich AMs. In sum, the present study shows that changes in the sustained response and coupling of the hippocampus and prefrontal cortex (PFC) underlie age-related reductions in episodic richness of the personal past.
dc.language eng
dc.relation.ispartof Neurobiol Aging
dc.relation.isversionof 10.1016/j.neurobiolaging.2010.11.007
dc.subject Acoustic Stimulation
dc.subject Adolescent
dc.subject Adult
dc.subject Aged
dc.subject Aging
dc.subject Female
dc.subject Hippocampus
dc.subject Humans
dc.subject Magnetic Resonance Imaging
dc.subject Male
dc.subject Memory, Episodic
dc.subject Mental Recall
dc.subject Middle Aged
dc.subject Prefrontal Cortex
dc.subject Reaction Time
dc.subject Young Adult
dc.title Age-related effects on the neural correlates of autobiographical memory retrieval.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/21190759
pubs.begin-page 1298
pubs.end-page 1310
pubs.issue 7
pubs.organisational-group Center for Cognitive Neuroscience
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Duke Science & Society
pubs.organisational-group Duke-UNC Center for Brain Imaging and Analysis
pubs.organisational-group Initiatives
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Psychiatry & Behavioral Sciences
pubs.organisational-group Psychiatry & Behavioral Sciences, Geriatric Behavioral Health
pubs.organisational-group Psychology and Neuroscience
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 33
dc.identifier.eissn 1558-1497


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record