Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation.

Ballen, Karen K

Logan, Brent R

Laughlin, Mary J

He, Wensheng

Ambruso, Daniel R

Armitage, Susan E

Beddard, Rachel L

Bhatla, Deepika

Hwang, William YK

Kiss, Joseph E

Koegler, Gesine

Kurtzberg, Joanne

Nagler, Arnon

Oh, David

Petz, Lawrence D

Price, Thomas H

Quinones, Ralph R

Ratanatharathorn, Voravit

Rizzo, J Douglas

Sazama, Kathleen

Scaradavou, Andromachi

Schuster, Michael W

Sender, Leonard S

Shpall, Elizabeth J

Spellman, Stephen R

Sutton, Millicent

Weitekamp, Lee Ann

Wingard, John R

Eapen, Mary

2022-03-23T19:25:41Z

2022-03-23T19:25:41Z

2015-04

2022-03-23T19:25:41Z

Variations in cord blood manufacturing and administration are common, and the optimal practice is not known. We compared processing and banking practices at 16 public cord blood banks (CBB) in the United States and assessed transplantation outcomes on 530 single umbilical cord blood (UCB) myeloablative transplantations for hematologic malignancies facilitated by these banks. UCB banking practices were separated into 3 mutually exclusive groups based on whether processing was automated or manual, units were plasma and red blood cell reduced, or buffy coat production method or plasma reduced. Compared with the automated processing system for units, the day 28 neutrophil recovery was significantly lower after transplantation of units that were manually processed and plasma reduced (red cell replete) (odds ratio, .19; P = .001) or plasma and red cell reduced (odds ratio, .54; P = .05). Day 100 survival did not differ by CBB. However, day 100 survival was better with units that were thawed with the dextran-albumin wash method compared with the "no wash" or "dilution only" techniques (odds ratio, 1.82; P = .04). In conclusion, CBB processing has no significant effect on early (day 100) survival despite differences in kinetics of neutrophil recovery.

S1083-8791(14)01436-0

1083-8791

1523-6536

https://hdl.handle.net/10161/24651

eng

Elsevier Inc.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

10.1016/j.bbmt.2014.12.017

Hematopoietic Stem Cells

Humans

Transplantation Conditioning

Cord Blood Stem Cell Transplantation

Adolescent

Adult

Child

Child, Preschool

Female

Male

Allografts

Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation.

Journal article

Kurtzberg, Joanne|0000-0002-3370-0703

688

695

4

Duke

School of Medicine

Clinical Science Departments

Institutes and Centers

Pathology

Pediatrics

Duke Cancer Institute

Institutes and Provost's Academic Units

Initiatives

Duke Innovation & Entrepreneurship

Pediatrics, Transplant and Cellular Therapy

Published

21