High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina.


Small bistratified cells (SBCs) in the primate retina carry a major blue-yellow opponent signal to the brain. We found that SBCs also carry signals from rod photoreceptors, with the same sign as S cone input. SBCs exhibited robust responses under low scotopic conditions. Physiological and anatomical experiments indicated that this rod input arose from the AII amacrine cell-mediated rod pathway. Rod and cone signals were both present in SBCs at mesopic light levels. These findings have three implications. First, more retinal circuits may multiplex rod and cone signals than were previously thought to, efficiently exploiting the limited number of optic nerve fibers. Second, signals from AII amacrine cells may diverge to most or all of the approximately 20 retinal ganglion cell types in the peripheral primate retina. Third, rod input to SBCs may be the substrate for behavioral biases toward perception of blue at mesopic light levels.





Published Version (Please cite this version)


Publication Info

Field, Greg D, Martin Greschner, Jeffrey L Gauthier, Carolina Rangel, Jonathon Shlens, Alexander Sher, David W Marshak, Alan M Litke, et al. (2009). High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina. Nat Neurosci, 12(9). pp. 1159–1164. 10.1038/nn.2353 Retrieved from https://hdl.handle.net/10161/9724.

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Greg D. Field

Adjunct Associate Professor of Neurobiology

My laboratory studies how the retina processes visual scenes and transmits this information to the brain.  We use multi-electrode arrays to record the activity of hundreds of retina neurons simultaneously in conjunction with transgenic mouse lines and chemogenetics to manipulate neural circuit function. We are interested in three major areas. First, we work to understand how neurons in the retina are functionally connected. Second we are studying how light-adaptation and circadian rhythms alter visual processing in the retina. Finally, we are working to understand the mechanisms of retinal degenerative conditions and we are investigating potential treatments in animal models.

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