Ultra-sharp metal and nanotube-based probes for applications in scanning microscopy and neural recording.

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2012-04-12

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Abstract

This paper discusses several methods for manufacturing ultra-sharp probes, with applications geared toward, but not limited to, scanning microscopy (STM, AFM) and intra-cellular recordings of neural signals. We present recipes for making tungsten, platinum/iridium alloy, and nanotube fibril tips. Electrical isolation methods using Parylene-C or PMMA are described.

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10.1063/1.3702802

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Borzenets, IV, I Yoon, MM Prior, BR Donald, RD Mooney and G Finkelstein (2012). Ultra-sharp metal and nanotube-based probes for applications in scanning microscopy and neural recording. Journal of applied physics, 111(7). pp. 74703–747036. 10.1063/1.3702802 Retrieved from https://hdl.handle.net/10161/19648.

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Scholars@Duke

Mooney

Richard Daniel Mooney

George Barth Geller Distinguished Professor for Research in Neurobiology

Our broad research goal is to understand the neural mechanisms by which experience guides learning, behavior, and perception. Our group explores the structure and function of sensorimotor circuits important to learned vocal communication in the songbird and to auditory-motor integration in the mouse. In the course of these explorations, my research group has developed a wide range of technical expertise in both avian and mouse models, including in vivo multiphoton neuronal imaging, chronic recording of neural activity in freely behaving animals, in vivo and in vitro intracellular recordings from identified neurons, and manipulation of neuronal activity using electrical, chemical and optogenetic methods. Our group also has extensive experience with viral transgenic methods to manipulate gene expression, including genes implicated in human neurological disorders. Together, these methods provide a broad technical approach to identify the neural circuit mechanisms important to vocal learning, auditory perception and communication.

Finkelstein

Gleb Finkelstein

Professor of Physics

Gleb Finkelstein is an experimentalist interested in physics of quantum nanostructures, such as Josephson junctions and quantum dots made of carbon nanotubes, graphene, and topological materials. These objects reveal a variety of interesting electronic properties that may form a basis for future quantum devices.


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