Common genetic variation and the control of HIV-1 in humans.
| dc.contributor.author | Fellay, Jacques | |
| dc.contributor.author | Ge, Dongliang | |
| dc.contributor.author | Shianna, Kevin V | |
| dc.contributor.author | Colombo, Sara | |
| dc.contributor.author | Ledergerber, Bruno | |
| dc.contributor.author | Cirulli, Elizabeth T | |
| dc.contributor.author | Urban, Thomas J | |
| dc.contributor.author | Zhang, Kunlin | |
| dc.contributor.author | Gumbs, Curtis E | |
| dc.contributor.author | Smith, Jason P | |
| dc.contributor.author | Castagna, Antonella | |
| dc.contributor.author | Cozzi-Lepri, Alessandro | |
| dc.contributor.author | De Luca, Andrea | |
| dc.contributor.author | Easterbrook, Philippa | |
| dc.contributor.author | Günthard, Huldrych F | |
| dc.contributor.author | Mallal, Simon | |
| dc.contributor.author | Mussini, Cristina | |
| dc.contributor.author | Dalmau, Judith | |
| dc.contributor.author | Martinez-Picado, Javier | |
| dc.contributor.author | Miro, José M | |
| dc.contributor.author | Obel, Niels | |
| dc.contributor.author | Wolinsky, Steven M | |
| dc.contributor.author | Martinson, Jeremy J | |
| dc.contributor.author | Detels, Roger | |
| dc.contributor.author | Margolick, Joseph B | |
| dc.contributor.author | Jacobson, Lisa P | |
| dc.contributor.author | Descombes, Patrick | |
| dc.contributor.author | Antonarakis, Stylianos E | |
| dc.contributor.author | Beckmann, Jacques S | |
| dc.contributor.author | O'Brien, Stephen J | |
| dc.contributor.author | Letvin, Norman L | |
| dc.contributor.author | McMichael, Andrew J | |
| dc.contributor.author | Haynes, Barton F | |
| dc.contributor.author | Carrington, Mary | |
| dc.contributor.author | Feng, Sheng | |
| dc.contributor.author | Telenti, Amalio | |
| dc.contributor.author | Goldstein, David B | |
| dc.contributor.author | NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) | |
| dc.contributor.editor | McCarthy, Mark I | |
| dc.coverage.spatial | United States | |
| dc.date.accessioned | 2011-06-21T17:31:15Z | |
| dc.date.issued | 2009-12 | |
| dc.description.abstract | To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians. | |
| dc.description.version | Version of Record | |
| dc.identifier | ||
| dc.identifier.eissn | 1553-7404 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.language.iso | en_US | |
| dc.publisher | Public Library of Science (PLoS) | |
| dc.relation.ispartof | PLoS Genet | |
| dc.relation.isversionof | 10.1371/journal.pgen.1000791 | |
| dc.relation.journal | Plos Genetics | |
| dc.subject | Adult | |
| dc.subject | Alleles | |
| dc.subject | Disease Progression | |
| dc.subject | Female | |
| dc.subject | Genetic Variation | |
| dc.subject | Genotype | |
| dc.subject | HIV Infections | |
| dc.subject | HIV-1 | |
| dc.subject | Humans | |
| dc.subject | Kaplan-Meier Estimate | |
| dc.subject | Major Histocompatibility Complex | |
| dc.subject | Male | |
| dc.subject | Phenotype | |
| dc.subject | Polymorphism, Single Nucleotide | |
| dc.subject | Viral Load | |
| dc.title | Common genetic variation and the control of HIV-1 in humans. | |
| dc.title.alternative | ||
| dc.type | Journal article | |
| duke.date.pubdate | 2009-12-0 | |
| duke.description.issue | 12 | |
| duke.description.volume | 5 | |
| pubs.author-url | ||
| pubs.begin-page | e1000791 | |
| pubs.issue | 12 | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Duke Center for Human Genome Variation | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Duke Human Vaccine Institute | |
| pubs.organisational-group | Duke Institute for Brain Sciences | |
| pubs.organisational-group | Faculty | |
| pubs.organisational-group | Immunology | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Medicine, Duke Human Vaccine Institute | |
| pubs.organisational-group | Molecular Genetics and Microbiology | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.publication-status | Published | |
| pubs.volume | 5 |