The clinical need for clustered AChR cell-based assay testing of seronegative MG.

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2022-06

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Abstract

Trial eligibility in myasthenia gravis (MG) remains largely dependent on a positive autoantibody serostatus. This significantly hinders seronegative MG (SNMG) patients from receiving potentially beneficial new treatments. In a subset of SNMG patients, acetylcholine receptor (AChR) autoantibodies are detectable by a clustered AChR cell-based assay (CBA). Of 99 SNMG patients from two academic U.S. centers, 18 (18.2%) tested positive by this assay. Autoantibody positivity was further validated in 17/18 patients. In a complementary experiment, circulating AChR-specific B cells were identified in a CBA-positive SNMG patient. These findings corroborate the clinical need for clustered AChR CBA testing when evaluating SNMG patients.

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Journal article

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Humans, Myasthenia Gravis, Receptors, Cholinergic, Autoantibodies, Biological Assay

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https://hdl.handle.net/10161/32487

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https://creativecommons.org/licenses/by-nc/4.0

Published Version (Please cite this version)

10.1016/j.jneuroim.2022.577850

Publication Info

Masi, Gianvito, Yingkai Li, Tabitha Karatz, Minh C Pham, Seneca R Oxendine, Richard J Nowak, Jeffrey T Guptill, Kevin C O'Connor, et al. (2022). The clinical need for clustered AChR cell-based assay testing of seronegative MG. Journal of neuroimmunology, 367. p. 577850. 10.1016/j.jneuroim.2022.577850 Retrieved from https://hdl.handle.net/10161/32487.

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Scholars@Duke

Li

Yingkai Li

Medical Instructor in the Department of Neurology
Guptill

Jeffrey Guptill

Adjunct Associate Professor in the Department of Neurology

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