PDK1 neddylation by Smurf1 drives Akt activation.

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2024-08

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https://hdl.handle.net/10161/32098

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https://creativecommons.org/licenses/by-nc/4.0

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10.1038/s41422-024-01020-4

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Manne, Rajesh Kumar, Rajni Kant and Hui-Kuan Lin (2024). PDK1 neddylation by Smurf1 drives Akt activation. Cell research, 35(2). pp. 95–96. 10.1038/s41422-024-01020-4 Retrieved from https://hdl.handle.net/10161/32098.

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RAJESHKUMAR MANNE

Research Associate, Senior
Lin

Hui-Kuan Lin

Fred and Janet Sanfilippo Distinguished Professor

The research interest in Dr. Lin lab is to understand oncogenic networks between oncogenes and tumor suppressor genes, dissect the regulatory mechanisms underlying  the crosstalk between ageing and cancer, to unravel the role of posttranslational modifications (PTMs) such as ubiquitination  and metabolism in diverse molecular and biological processes important for cancer progression and metastasis, cancer stem regulation, cancer immunity and drug resistance by using biochemical and molecular approaches along with and genetic mouse models, and finally to develop small molecule inhibitors and antibodies targeting critical oncogenic signaling and metabolic vulnerabilities for cancer treatment. His research goals aim to not only reveal fundamental insights and concepts for cancer biology and cancer immunity, but also develop novel paradigms and therapeutic strategies for targeting human cancer and overcoming drug resistance.

Research interests include:

  • Crosstalk between oncogenic and tumor suppressor networks
  • Posttranslational modifications in signaling and cancer
  • Cancer progression and metastasis
  • Biology of normal and cancer stem cells
  • Metabolism in cancer and ageing

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