Cytokine biomarkers in tear film for primary open-angle glaucoma.

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2017

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Abstract

PURPOSE: To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). METHODS: Patients without POAG and eye drop-naïve patients with newly diagnosed POAG were recruited from an academic hospital-based glaucoma practice. Tear films of recruited patients were obtained and analyzed using a multiplex, high-sensitivity electrochemiluminescent enzyme-linked immunosorbent assay for proinflammatory cytokines (IFNγ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, and TNFα). RESULTS: Mean concentrations of tear film cytokines were lower in the glaucoma group for 8 of 10 cytokines tested. IL-12p70 (3.94±2.19 pg/mL in control vs 2.31±1.156 pg/mL in POAG;P=0.035) was significantly lower in the tear film of patients with newly diagnosed POAG. CONCLUSION: Proinflammatory cytokines were lower in eye drop-naïve newly diagnosed glaucoma patients. Tear film cytokine profiles may be used as biomarkers of early POAG.

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10.2147/OPTH.S125364

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Gupta, Divakar, Joanne C Wen, Janet L Huebner, Sandra Stinnett, Virginia B Kraus, Henry C Tseng and Molly Walsh (2017). Cytokine biomarkers in tear film for primary open-angle glaucoma. Clin Ophthalmol, 11. pp. 411–416. 10.2147/OPTH.S125364 Retrieved from https://hdl.handle.net/10161/16164.

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Scholars@Duke

Gupta

Divakar Gupta

Associate Professor of Ophthalmology

Divakar Gupta, MD is a board certified, fellowship-trained ophthalmologist specializing in the medical and surgical treatment of glaucoma and cataracts.  He performs both traditional glaucoma surgery such as trabeculectomy and glaucoma tube shunts, as well as cutting-edge Minimally Invasive Glaucoma Surgery (MIGS).  He is trained in the latest surgical techniques of cataract and laser-assisted cataract surgery.  Dr. Gupta also offers premium intraocular lenses for cataract surgery patients interested in astigmatic correction and/or presbyopia correction.

He has a clinical and research interest in early diagnosis of glaucoma and improving treatment outcomes. His research focuses on novel ways to use optical imaging and technology to identify and manage glaucoma.  Dr. Gupta also spends time teaching and lecturing trainees and eye professionals at the Duke Eye Center and in the community.  When he is not working, he spends his time watching Duke Basketball, playing tennis, and enjoys cooking.

Stinnett

Sandra Sue Stinnett

Associate Professor of Biostatistics & Bioinformatics

Analysis of data for ophthalmology including observational studies and clinical trials. Assessment of reproducibility in grading measurements for ophthalmic studies. Teaching medical statistics.

Kraus

Virginia Byers Kraus

Mary Bernheim Distinguished Professor of Medicine

Virginia Byers Kraus, MD, PhD, is the Mary Bernheim Distinguished Professor of Medicine, Professor of Orthopaedic Surgery, Professor of Pathology and a faculty member of the Duke Molecular Physiology Institute in the Duke University School of Medicine. She is a practicing Rheumatologist with over 30 years’ experience in translational musculoskeletal research focusing on osteoarthritis, the most common of all arthritides. She trained at Brown University (ScB 1979), Duke University (MD 1982, PhD 1993) and the Duke University School of Medicine (Residency in Internal Medicine and Fellowship in Rheumatology). Her career has focused on elucidating osteoarthritis pathogenesis and translational research into the discovery and validation of biomarkers for early osteoarthritis detection, prediction of progression, monitoring of disease status, and facilitation of therapeutic developments. She is co-PI of the Foundation for NIH Biomarkers Consortium Osteoarthritis project. Trained as a molecular biologist and a Rheumatologist, she endeavors to study disease from bedside to bench.

Walsh

Molly McCarthy Walsh

Assistant Professor of Ophthalmology

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