Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states.

dc.contributor.author

Bolding, Kevin A

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Nagappan, Shivathmihai

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Han, Bao-Xia

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Wang, Fan

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Franks, Kevin M

dc.date.accessioned

2020-08-03T22:04:58Z

dc.date.available

2020-08-03T22:04:58Z

dc.date.issued

2020-07-14

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2020-08-03T22:04:54Z

dc.description.abstract

Pattern completion, or the ability to retrieve stable neural activity patterns from noisy or partial cues, is a fundamental feature of memory. Theoretical studies indicate that recurrently connected auto-associative or discrete attractor networks can perform this process. Although pattern completion and attractor dynamics have been observed in various recurrent neural circuits, the role recurrent circuitry plays in implementing these processes remains unclear. In recordings from head-fixed mice, we found that odor responses in olfactory bulb degrade under ketamine/xylazine anesthesia while responses immediately downstream, in piriform cortex, remain robust. Recurrent connections are required to stabilize cortical odor representations across states. Moreover, piriform odor representations exhibit attractor dynamics, both within and across trials, and these are also abolished when recurrent circuitry is eliminated. Here, we present converging evidence that recurrently-connected piriform populations stabilize sensory representations in response to degraded inputs, consistent with an auto-associative function for piriform cortex supported by recurrent circuitry.

dc.identifier

53125

dc.identifier.issn

2050-084X

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2050-084X

dc.identifier.uri

https://hdl.handle.net/10161/21276

dc.language

eng

dc.publisher

eLife Sciences Publications, Ltd

dc.relation.ispartof

eLife

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10.7554/elife.53125

dc.subject

cortical circuits

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mouse

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neuroscience

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olfaction

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pattern completion

dc.title

Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states.

dc.type

Journal article

duke.contributor.orcid

Wang, Fan|0000-0003-2988-0614

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School of Medicine

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Neurobiology

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Duke Institute for Brain Sciences

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Duke

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Basic Science Departments

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University Institutes and Centers

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Institutes and Provost's Academic Units

pubs.publication-status

Published

pubs.volume

9

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