Spine microdomains for postsynaptic signaling and plasticity.

dc.contributor.author

Newpher, Thomas M

dc.contributor.author

Ehlers, Michael D

dc.date.accessioned

2023-05-16T19:28:48Z

dc.date.available

2023-05-16T19:28:48Z

dc.date.issued

2009-05

dc.date.updated

2023-05-16T19:28:47Z

dc.description.abstract

Changes in the molecular composition and signaling properties of excitatory glutamatergic synapses onto dendritic spines mediate learning-related plasticity in the mammalian brain. This molecular adaptation serves as the most celebrated cell biological model for learning and memory. Within their micron-sized dimensions, dendritic spines restrict the diffusion of signaling molecules and spatially confine the activation of signal transduction pathways. Much of this local regulation occurs by spatial compartmentalization of glutamate receptors. Here, we review recently identified cell biological mechanisms regulating glutamate receptor mobility within individual dendritic spines. We discuss the emerging functions of glutamate receptors residing within sub-spine microdomains and propose a model for distinct signaling platforms with specialized functions in synaptic plasticity.

dc.identifier

S0962-8924(09)00057-9

dc.identifier.issn

0962-8924

dc.identifier.issn

1879-3088

dc.identifier.uri

https://hdl.handle.net/10161/27387

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

Trends in cell biology

dc.relation.isversionof

10.1016/j.tcb.2009.02.004

dc.subject

Hippocampus

dc.subject

Dendritic Spines

dc.subject

Synapses

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Membrane Microdomains

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Animals

dc.subject

Humans

dc.subject

Receptors, Glutamate

dc.subject

Synaptic Transmission

dc.subject

Neuronal Plasticity

dc.title

Spine microdomains for postsynaptic signaling and plasticity.

dc.type

Journal article

duke.contributor.orcid

Newpher, Thomas M|0000-0001-9920-7631

pubs.begin-page

218

pubs.end-page

227

pubs.issue

5

pubs.organisational-group

Duke

pubs.organisational-group

Trinity College of Arts & Sciences

pubs.organisational-group

Psychology & Neuroscience

pubs.organisational-group

Institutes and Provost's Academic Units

pubs.organisational-group

University Institutes and Centers

pubs.organisational-group

Duke Institute for Brain Sciences

pubs.publication-status

Published

pubs.volume

19

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