Generalized Linear Binning to Compare Hyperpolarized 129Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI.

He, Mu

Wang, Ziyi

Rankine, Leith

Luo, Sheng

Nouls, John

Virgincar, Rohan

Mammarappallil, Joseph

Driehuys, Bastiaan

2020-01-01T15:43:51Z

2020-01-01T15:43:51Z

2019-11-27

2020-01-01T15:43:47Z

RATIONALE:Hyperpolarized 129Xe ventilation MRI is typically acquired using multislice fast gradient recalled echo (GRE), but interleaved 3D radial 129Xe gas transfer MRI now provides dissolved-phase and ventilation images from a single breath. To investigate whether these ventilation images provide equivalent quantitative metrics, we introduce generalized linear binning analysis. METHODS:This study included 36 patients who had undergone both multislice GRE ventilation and 3D radial gas exchange imaging. Images were then quantified by linear binning to classify voxels into one of four clusters: ventilation defect percentage (VDP), Low-, Medium- or High-ventilation percentage (LVP, MVP, HVP). For 3D radial images, linear binning thresholds were generalized using a Box-Cox rescaled reference histogram. We compared the cluster populations from the two ventilation acquisitions both numerically and spatially. RESULTS:Interacquisition Bland-Altman limits of agreement for the clusters between 3D radial vs GRE were (-7% to 5%) for VDP, (-10% to 14%) for LVP, and (-8% to 8%) for HVP. While binning maps were qualitatively similar between acquisitions, their spatial overlap was modest for VDP (Dice = 0.5 ± 0.2), and relatively poor for LVP (0.3 ± 0.1) and HVP (0.2 ± 0.1). CONCLUSION:Both acquisitions yield reasonably concordant VDP and qualitatively similar maps. However, poor regional agreement (Dice) suggests that the two acquisitions cannot yet be used interchangeably. However, further improvements in 3D radial resolution and reconciliation of bias field correction may well obviate the need for a dedicated ventilation scan in many cases.

S1076-6332(19)30530-6

1076-6332

1878-4046

https://hdl.handle.net/10161/19675

eng

Elsevier BV

Academic radiology

10.1016/j.acra.2019.10.016

3D Radial

Acquisition

Hyperpolarized (129)Xe MRI

Multislice GRE

Quantification

Generalized Linear Binning to Compare Hyperpolarized 129Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI.

Journal article

Luo, Sheng|0000-0003-4214-5809

Driehuys, Bastiaan|0000-0002-1236-4210

School of Medicine

Duke

Radiology

Clinical Science Departments

Duke Clinical Research Institute

Institutes and Centers

Biostatistics & Bioinformatics

Basic Science Departments

Published