Breakthrough invasive fungal infections: Who is at risk?
| dc.contributor.author | Jenks, Jeffrey D | |
| dc.contributor.author | Cornely, Oliver A | |
| dc.contributor.author | Chen, Sharon C-A | |
| dc.contributor.author | Thompson, George R | |
| dc.contributor.author | Hoenigl, Martin | |
| dc.date.accessioned | 2023-08-01T17:47:46Z | |
| dc.date.available | 2023-08-01T17:47:46Z | |
| dc.date.issued | 2020-10 | |
| dc.date.updated | 2023-08-01T17:47:46Z | |
| dc.description.abstract | The epidemiology of invasive fungal infections (IFIs) in immunocompromised individuals has changed over the last few decades, partially due to the increased use of antifungal agents to prevent IFIs. Although this strategy has resulted in an overall reduction in IFIs, a subset of patients develop breakthrough IFIs with substantial morbidity and mortality in this population. Here, we review the most significant risk factors for breakthrough IFIs in haematology patients, solid organ transplant recipients, and patients in the intensive care unit, focusing particularly on host factors, and highlight areas that require future investigation. | |
| dc.identifier.issn | 0933-7407 | |
| dc.identifier.issn | 1439-0507 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Wiley | |
| dc.relation.ispartof | Mycoses | |
| dc.relation.isversionof | 10.1111/myc.13148 | |
| dc.subject | Humans | |
| dc.subject | Aspergillus | |
| dc.subject | Candida | |
| dc.subject | Fusarium | |
| dc.subject | Penicillium | |
| dc.subject | Mucorales | |
| dc.subject | Opportunistic Infections | |
| dc.subject | Mycoses | |
| dc.subject | Hematologic Neoplasms | |
| dc.subject | Neutropenia | |
| dc.subject | Genetic Predisposition to Disease | |
| dc.subject | Triazoles | |
| dc.subject | Fluconazole | |
| dc.subject | Adrenal Cortex Hormones | |
| dc.subject | Antifungal Agents | |
| dc.subject | Organ Transplantation | |
| dc.subject | Risk Factors | |
| dc.subject | Immunocompromised Host | |
| dc.subject | Intensive Care Units | |
| dc.subject | Echinocandins | |
| dc.subject | Central Venous Catheters | |
| dc.subject | Invasive Fungal Infections | |
| dc.title | Breakthrough invasive fungal infections: Who is at risk? | |
| dc.type | Journal article | |
| duke.contributor.orcid | Jenks, Jeffrey D|0000-0001-6632-9587 | |
| pubs.begin-page | 1021 | |
| pubs.end-page | 1032 | |
| pubs.issue | 10 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Medicine, Infectious Diseases | |
| pubs.publication-status | Published | |
| pubs.volume | 63 |
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