Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe?

Abstract

<jats:p>Nonalcoholic steatohepatitis (NASH) is a subtype of nonalcoholic fatty liver disease that is characterised by steatosis, chronic inflammation, and hepatocellular injury with or without fibrosis. The role and activation of macrophages in the pathogenesis of NASH is complex and is being studied for possible therapeutic options to help the millions of people diagnosed with the disease. The purpose of this review is to discuss the pathogenesis of NASH through the activation and role of Kupffer cells and other macrophages in causing inflammation and progression of NASH. Furthermore, this review aims to outline some of the current therapeutic options targeting the pathogenesis of NASH.</jats:p>

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Published Version (Please cite this version)

10.33590/emjhepatol/10312252

Publication Info

Grunhut, Joel, Wei Wang, Berk Aykut, Inderdeep Gakhal, Alejandro Torres-Hernandez and George Miller (n.d.). Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe?. EMJ Hepatology. pp. 100–109. 10.33590/emjhepatol/10312252 Retrieved from https://hdl.handle.net/10161/30188.

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Aykut

Berk Aykut

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College/University: Ruprecht Karl University of Heidelberg

Medical School: Ruprecht Karl University of Heidelberg


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