<i>ist-1/IRS1</i> affects L1 starvation resistance in <i>daf-16/FoxO-</i> dependent and independent fashion.
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2025-01
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The mammalian IRS1 gene is an important adaptor for the insulin and insulin-like growth factor receptors, but its sole homolog in the nematode C. elegans , ist-1 , has received relatively little attention. We show that ist-1 /IRS1 has modest effects on L1 starvation resistance, with two null mutants increasing larval growth and reproduction after recovery from extended L1 arrest. ist-1 /IRS1 mutants increase nuclear localization of DAF-16 /FoxO, a critical effector of insulin/IGF signaling, in starved L1 larvae, consistent with IST-1 /IRS1 transducing DAF-2 /IGFR signaling. However, epistasis analysis suggests that ist-1 /IRS1 also functions independently of daf-16 /FoxO , suggesting additional, novel function.
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Chen, Jingxian, Ainsley R Scheiner, Ivan B Falsztyn and L Ryan Baugh (2025). <i>ist-1/IRS1</i> affects L1 starvation resistance in <i>daf-16/FoxO-</i> dependent and independent fashion. microPublication biology, 2025. 10.17912/micropub.biology.001648 Retrieved from https://hdl.handle.net/10161/33055.
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L. Ryan Baugh
The Baugh Lab is interested in phenotypic plasticity and developmental robustness despite variable environmental conditions. We use the roundworm C. elegans to study how animals adapt to starvation over different time scales using functional genomics (bulk and single-cell) as well as statistical, quantitative, and molecular genetics. Our research questions revolve around how gene regulation and development are governed by nutrient availability, how animals acclimate to survive starvation, and the mechanisms underlying adult consequences of early life starvation. We are gaining insight into the genetic basis of natural variation among wild strains, the function of conserved tumor suppressors, epigenetic effects of starvation, and how early life experience affects adult disease.
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