Endpoint surrogacy in oncology Phase 3 randomised controlled trials.

Abstract

Endpoint surrogacy is an important concept in oncology trials. Using a surrogate endpoint like progression-free survival as the primary endpoint-instead of overall survival-would lead to a potential faster drug approval and therefore more cancer patients with an earlier opportunity to receive the newly approved drugs.

Department

Description

Provenance

Citation

Published Version (Please cite this version)

10.1038/s41416-020-0896-5

Publication Info

Zhang, Jianrong, Meagan R Pilar, Xiaofei Wang, Jingxia Liu, Herbert Pang, Ross C Brownson, Graham A Colditz, Wenhua Liang, et al. (2020). Endpoint surrogacy in oncology Phase 3 randomised controlled trials. British journal of cancer, 123(3). pp. 333–334. 10.1038/s41416-020-0896-5 Retrieved from https://hdl.handle.net/10161/30411.

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Scholars@Duke

Wang

Xiaofei Wang

Professor of Biostatistics & Bioinformatics

Design and Analysis of Clinical Trials
Methods for Diagnostic and Predictive Medicine
Survival Analysis
Causal Inference
Analysis of Data from Multiple Sources


Pang

Herbert Pang

Adjunct Assistant Professor in the Department of Biostatistics & Bioinformatics

Classification and Predictive Models
Design and Analysis of Biomarker Clinical Trials
Genomics
Pathway Analysis


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