How genes influence life span: the biodemography of human survival.
| dc.contributor.author | Yashin, Anatoliy I | |
| dc.contributor.author | Wu, Deqing | |
| dc.contributor.author | Arbeev, Konstantin G | |
| dc.contributor.author | Stallard, Eric | |
| dc.contributor.author | Land, Kenneth C | |
| dc.contributor.author | Ukraintseva, Svetlana V | |
| dc.coverage.spatial | United States | |
| dc.date.accessioned | 2017-06-07T18:36:25Z | |
| dc.date.available | 2017-06-07T18:36:25Z | |
| dc.date.issued | 2012-08 | |
| dc.description.abstract | BACKGROUND: In genome-wide association studies (GWAS) of human life span, none of the genetic variants has reached the level of genome-wide statistical significance. The roles of such variants in life span regulation remain unclear. DATA AND METHOD: A biodemographic analyses was done of genetic regulation of life span using data on low-significance longevity alleles selected in the earlier GWAS of the original Framingham cohort. RESULTS: Age-specific survival curves considered as functions of the number of longevity alleles exhibit regularities known in demography as "rectangularization" of survival curves. The presence of such pattern confirms observations from experimental studies that regulation of life span involves genes responsible for stress resistance. CONCLUSION: Biodemographic analyses could provide important information about the properties of genes affecting phenotypic traits. | |
| dc.identifier | ||
| dc.identifier.eissn | 1557-8577 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Mary Ann Liebert Inc | |
| dc.relation.ispartof | Rejuvenation Res | |
| dc.relation.isversionof | 10.1089/rej.2011.1290 | |
| dc.subject | Aging | |
| dc.subject | Alleles | |
| dc.subject | Cohort Studies | |
| dc.subject | Demography | |
| dc.subject | Genome-Wide Association Study | |
| dc.subject | Humans | |
| dc.subject | Longevity | |
| dc.subject | Phenotype | |
| dc.title | How genes influence life span: the biodemography of human survival. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Arbeev, Konstantin G|0000-0002-4195-7832 | |
| duke.contributor.orcid | Land, Kenneth C|0000-0002-9551-7314 | |
| pubs.author-url | ||
| pubs.begin-page | 374 | |
| pubs.end-page | 380 | |
| pubs.issue | 4 | |
| pubs.organisational-group | Center for Population Health & Aging | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Duke Population Research Center | |
| pubs.organisational-group | Duke Population Research Institute | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Sanford School of Public Policy | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Social Science Research Institute | |
| pubs.organisational-group | Sociology | |
| pubs.organisational-group | Staff | |
| pubs.organisational-group | Trinity College of Arts & Sciences | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.publication-status | Published | |
| pubs.volume | 15 |
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