Nonsteroidal Anti-inflammatory Drugs and Risk of Incident Heart Failure: A Systematic Review and Meta-analysis of Observational Studies.
| dc.contributor.author | Ungprasert, Patompong | |
| dc.contributor.author | Srivali, Narat | |
| dc.contributor.author | Thongprayoon, Charat | |
| dc.date.accessioned | 2023-11-23T12:30:53Z | |
| dc.date.available | 2023-11-23T12:30:53Z | |
| dc.date.issued | 2016-02 | |
| dc.date.updated | 2023-11-23T12:30:51Z | |
| dc.description.abstract | BackgroundThe association between the development of heart failure (HF) and use of nonsteroidal anti-inflammatory drugs (NSAIDs) is not well established.HypothesisUse of NSAIDs may increase the risk of incident HF.MethodsWe conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio comparing risk of incident HF in NSAID users vs nonusers. Pooled risk ratios (RR) and 95% confidence intervals (CI) for all NSAIDs and both subclasses (conventional NSAIDs and highly selective cyclooxygenase-2 inhibitors [COXIBs]) were calculated using a random-effect, generic inverse variance method.ResultsSeven studies with 7,543,805 participants were identified and included in our data analysis. Use of NSAIDs was associated with a significantly higher risk of developing HF, with a pooled RR of 1.17 (95% CI: 1.01-1.36). Subgroup analysis showed a significantly elevated risk among users of conventional NSAIDs (RR: 1.35, 95% CI: 1.15-1.57) but not users of COXIBs (RR: 1.03, 95% CI: 0.92-1.16).ConclusionsA significantly elevated risk of incident HF was observed among users of NSAIDs. | |
| dc.identifier.issn | 0160-9289 | |
| dc.identifier.issn | 1932-8737 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Wiley | |
| dc.relation.ispartof | Clinical cardiology | |
| dc.relation.isversionof | 10.1002/clc.22502 | |
| dc.subject | Humans | |
| dc.subject | Anti-Inflammatory Agents, Non-Steroidal | |
| dc.subject | Incidence | |
| dc.subject | Odds Ratio | |
| dc.subject | Risk Assessment | |
| dc.subject | Risk Factors | |
| dc.subject | Chi-Square Distribution | |
| dc.subject | Heart Failure | |
| dc.subject | Observational Studies as Topic | |
| dc.title | Nonsteroidal Anti-inflammatory Drugs and Risk of Incident Heart Failure: A Systematic Review and Meta-analysis of Observational Studies. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Srivali, Narat|0000-0002-6945-329X | |
| pubs.begin-page | 111 | |
| pubs.end-page | 118 | |
| pubs.issue | 2 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Medicine, Pulmonary, Allergy, and Critical Care Medicine | |
| pubs.publication-status | Published | |
| pubs.volume | 39 |
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