Solution NMR studies of the plant peptide hormone CEP inform function.
| dc.contributor.author | Bobay, Benjamin G | |
| dc.contributor.author | DiGennaro, Peter | |
| dc.contributor.author | Scholl, Elizabeth | |
| dc.contributor.author | Imin, Nijat | |
| dc.contributor.author | Djordjevic, Michael A | |
| dc.contributor.author | Mck Bird, David | |
| dc.date.accessioned | 2023-09-01T14:08:23Z | |
| dc.date.available | 2023-09-01T14:08:23Z | |
| dc.date.issued | 2013-12 | |
| dc.date.updated | 2023-09-01T14:08:22Z | |
| dc.description.abstract | The C-terminally Encoded Peptide (CEP) family of regulatory peptides controls root development in vascular plants. Here, we present the first NMR structures of CEP. We show that root-knot nematode (RKN: Meloidogyne spp.) also encodes CEP, presumably to mimic plant CEP as part of their stereotypic, parasitic interaction with vascular plants. Molecular dynamics simulations of plant- and nematode-encoded CEP displaying known posttranslational modifications (PTM) provided insight into the structural effects of PTM and the conformational plasticity and rigidity of CEP. Potential mechanisms of action are discussed with respect to the structure and sampling of conformational space. | |
| dc.identifier | S0014-5793(13)00803-X | |
| dc.identifier.issn | 0014-5793 | |
| dc.identifier.issn | 1873-3468 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Wiley | |
| dc.relation.ispartof | FEBS letters | |
| dc.relation.isversionof | 10.1016/j.febslet.2013.10.033 | |
| dc.subject | Animals | |
| dc.subject | Tylenchoidea | |
| dc.subject | Plants | |
| dc.subject | Plant Growth Regulators | |
| dc.subject | Nuclear Magnetic Resonance, Biomolecular | |
| dc.subject | Plant Diseases | |
| dc.subject | Molecular Mimicry | |
| dc.subject | Amino Acid Sequence | |
| dc.subject | Sequence Homology, Amino Acid | |
| dc.subject | Genome, Plant | |
| dc.subject | Models, Molecular | |
| dc.subject | Molecular Sequence Data | |
| dc.subject | Root Nodules, Plant | |
| dc.subject | Host-Parasite Interactions | |
| dc.subject | Molecular Dynamics Simulation | |
| dc.title | Solution NMR studies of the plant peptide hormone CEP inform function. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Bobay, Benjamin G|0000-0003-4775-3686 | |
| pubs.begin-page | 3979 | |
| pubs.end-page | 3985 | |
| pubs.issue | 24 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Radiology | |
| pubs.publication-status | Published | |
| pubs.volume | 587 |
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