Biomarkers of PTA

Golightly, YM

Adams, SB

Kraus, VB

2015-11-10T22:18:41Z

2015-01-01

© Springer Science+Business Media New York 2015.Prognostic biomarkers may indicate the likelihood of disease development and speed of progression or may serve as predictive indicators of responsiveness to treatment. Joint injuries, particularly severe injuries, may result in post-traumatic osteoarthritis (PTOA), and pre- and post-injury prognostic biomarkers are needed to enhance primary and secondary prevention approaches for PTOA. Several macromolecules from joint structures found in serum, urine, and synovial fluid are promising biochemical markers for monitoring joint metabolism and health before and after joint injury. The use of metabolic profiling (analysis of small molecules) as a predictive tool for osteoarthritis (OA) has increased in the past decade. Although there is some question as to whether PTOA and idiopathic OA are comparable conditions, there is some evidence to suggest that components of their pathogenesis are similar. Potentially, biomarkers important to the high-risk PTOA profile translate to idiopathic OA. Further work is needed to confirm the utility of macromolecules and metabolites as biomarkers for PTOA, particularly focusing on those strongly correlated to clinical efficacy measures important to the patient (e.g., symptoms, physical function, and quality of life) and the causal pathway of PTOA.

9781489976062

https://hdl.handle.net/10161/10860

Springer US

Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management

10.1007/978-1-4899-7606-2_25

Biomarkers of PTA

Book section

Adams, SB|0000-0003-1020-1167

Kraus, VB|0000-0001-8173-8258

317

330

Clinical Science Departments

Duke

Duke Molecular Physiology Institute

Institutes and Centers

Medicine

Medicine, Rheumatology and Immunology

Orthopaedics

Pathology

School of Medicine

Published