Comparison of a Blood Self-Collection System with Routine Phlebotomy for SARS-CoV-2 Antibody Testing.

dc.contributor.author

Wixted, Douglas

dc.contributor.author

Neighbors, Coralei E

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Pieper, Carl F

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Wu, Angie

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Kingsbury, Carla

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Register, Heidi

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Petzold, Elizabeth

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Newby, L Kristin

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Woods, Christopher W

dc.date.accessioned

2023-10-18T23:42:12Z

dc.date.available

2023-10-18T23:42:12Z

dc.date.issued

2022-07

dc.date.updated

2023-10-18T23:42:10Z

dc.description.abstract

The Coronavirus Disease 2019 (COVID-19) pandemic forced researchers to reconsider in-person assessments due to transmission risk. We conducted a pilot study to evaluate the feasibility of using the Tasso-SST (Tasso, Inc, Seattle, Washington) device for blood self-collection for use in SARS-CoV-2 antibody testing in an ongoing COVID-19 prevalence and immunity research study. 100 participants were recruited between January and March 2021 from a previously identified sub-cohort of the Cabarrus County COVID-19 Prevalence and Immunity (C3PI) Study who were under-going bimonthly COVID-19 antibody testing. Participants were given a Tasso-SST kit and asked to self-collect blood during a scheduled visit where trained laboratory personnel performed routine phlebotomy. All participants completed an after-visit survey about their experience. Overall, 70.0% of participants were able to collect an adequate sample for testing using the device. Among those with an adequate sample, there was a high concordance in results between the Tasso-SST and phlebotomy blood collection methods (Cohen’s kappa coefficient = 0.88, Interclass correlation coefficient 0.98 [0.97, 0.99], p < 0.0001). The device received a high-level (90.0%) of acceptance among all participants. Overall, the Tasso-SST could prove to be a valuable tool for seroprevalence testing. However, future studies in larger, diverse populations over longer periods may provide a better understanding of device usability and acceptance among older participants and those with comorbidities in various use scenarios.

dc.identifier

diagnostics12081857

dc.identifier.issn

2075-4418

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2075-4418

dc.identifier.uri

https://hdl.handle.net/10161/29285

dc.language

eng

dc.publisher

MDPI AG

dc.relation.ispartof

Diagnostics (Basel, Switzerland)

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10.3390/diagnostics12081857

dc.subject

COVID-19

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SARS-CoV-2

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Tasso-SST

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antibody testing

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capillary blood

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coronavirus

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infectious disease

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self-collection

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user acceptance

dc.title

Comparison of a Blood Self-Collection System with Routine Phlebotomy for SARS-CoV-2 Antibody Testing.

dc.type

Journal article

duke.contributor.orcid

Wixted, Douglas|0000-0002-6128-7813

duke.contributor.orcid

Neighbors, Coralei E|0000-0002-0367-2983

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Pieper, Carl F|0000-0003-4809-1725

duke.contributor.orcid

Newby, L Kristin|0000-0002-6394-8187

duke.contributor.orcid

Woods, Christopher W|0000-0001-7240-2453

pubs.begin-page

1857

pubs.issue

8

pubs.organisational-group

Duke

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School of Medicine

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Student

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Staff

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Basic Science Departments

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Clinical Science Departments

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Institutes and Centers

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Biostatistics & Bioinformatics

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Medicine

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Pathology

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Medicine, Cardiology

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Medicine, Infectious Diseases

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Duke Clinical Research Institute

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Duke Human Vaccine Institute

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Institutes and Provost's Academic Units

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University Institutes and Centers

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Duke Global Health Institute

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Population Health Sciences

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Duke Clinical & Translational Science Institute

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Biostatistics & Bioinformatics, Division of Biostatistics

pubs.publication-status

Published

pubs.volume

12

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