Lung Transplantation and the Era of the Sensitized Patient.

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2021-01

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Abstract

Long term outcomes in lung transplant are limited by the development of chronic lung allograft dysfunction (CLAD). Within the past several decades, antibody-mediated rejection (AMR) has been recognized as a risk factor for CLAD. The presence of HLA antibodies in lung transplant candidates, "sensitized patients" may predispose patients to AMR, CLAD, and higher mortality after transplant. This review will discuss issues surrounding the sensitized patient, including mechanisms of sensitization, implications within lung transplant, and management strategies.

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Humans, Immunosuppressive Agents, Isoantibodies, HLA Antigens, Histocompatibility Testing, Treatment Outcome, Lung Transplantation, Risk Assessment, Risk Factors, Transplantation Tolerance, Histocompatibility, Graft Rejection, Graft Survival, Time Factors

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https://hdl.handle.net/10161/26148

Published Version (Please cite this version)

10.3389/fimmu.2021.689420

Publication Info

Young, Katherine A, Hakim A Ali, Kristi J Beermann, John M Reynolds and Laurie D Snyder (2021). Lung Transplantation and the Era of the Sensitized Patient. Frontiers in immunology, 12. p. 689420. 10.3389/fimmu.2021.689420 Retrieved from https://hdl.handle.net/10161/26148.

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Scholars@Duke

Young

Katherine Young

Assistant Professor of Medicine
Ali

Hakim Azfar Ali

Associate Professor of Medicine
Reynolds

John Michael Reynolds

Professor of Medicine

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