Lung Transplantation and the Era of the Sensitized Patient.
| dc.contributor.author | Young, Katherine A | |
| dc.contributor.author | Ali, Hakim A | |
| dc.contributor.author | Beermann, Kristi J | |
| dc.contributor.author | Reynolds, John M | |
| dc.contributor.author | Snyder, Laurie D | |
| dc.date.accessioned | 2022-11-01T14:19:20Z | |
| dc.date.available | 2022-11-01T14:19:20Z | |
| dc.date.issued | 2021-01 | |
| dc.date.updated | 2022-11-01T14:19:20Z | |
| dc.description.abstract | Long term outcomes in lung transplant are limited by the development of chronic lung allograft dysfunction (CLAD). Within the past several decades, antibody-mediated rejection (AMR) has been recognized as a risk factor for CLAD. The presence of HLA antibodies in lung transplant candidates, "sensitized patients" may predispose patients to AMR, CLAD, and higher mortality after transplant. This review will discuss issues surrounding the sensitized patient, including mechanisms of sensitization, implications within lung transplant, and management strategies. | |
| dc.identifier.issn | 1664-3224 | |
| dc.identifier.issn | 1664-3224 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Frontiers Media SA | |
| dc.relation.ispartof | Frontiers in immunology | |
| dc.relation.isversionof | 10.3389/fimmu.2021.689420 | |
| dc.subject | Humans | |
| dc.subject | Immunosuppressive Agents | |
| dc.subject | Isoantibodies | |
| dc.subject | HLA Antigens | |
| dc.subject | Histocompatibility Testing | |
| dc.subject | Treatment Outcome | |
| dc.subject | Lung Transplantation | |
| dc.subject | Risk Assessment | |
| dc.subject | Risk Factors | |
| dc.subject | Transplantation Tolerance | |
| dc.subject | Histocompatibility | |
| dc.subject | Graft Rejection | |
| dc.subject | Graft Survival | |
| dc.subject | Time Factors | |
| dc.title | Lung Transplantation and the Era of the Sensitized Patient. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Ali, Hakim A|0000-0002-8953-7693 | |
| duke.contributor.orcid | Reynolds, John M|0000-0003-4766-8852 | |
| duke.contributor.orcid | Snyder, Laurie D|0000-0002-5962-2184 | |
| pubs.begin-page | 689420 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Medicine, Pulmonary, Allergy, and Critical Care Medicine | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.publication-status | Published | |
| pubs.volume | 12 |
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