Cannabis use and the sperm epigenome: a budding concern?

dc.contributor.author

Schrott, Rose

dc.contributor.author

Murphy, Susan K

dc.date.accessioned

2020-04-01T16:53:24Z

dc.date.available

2020-04-01T16:53:24Z

dc.date.issued

2020-01

dc.date.updated

2020-04-01T16:53:23Z

dc.description.abstract

The United States is swiftly moving toward increased legalization of medical and recreational cannabis. Currently considered the most commonly used illicit psychoactive drug, recreational cannabis is legal in 11 states and Washington, DC, and male use is an important and understudied concern. Questions remain, however, about the potential long-term consequences of this exposure and how cannabis might impact the epigenetic integrity of sperm in such a way that could influence the health and development of offspring. This review summarizes cannabis use and potency in the USA, provides a brief overview of DNA methylation as an epigenetic mechanism that is vulnerable in sperm to environmental exposures including cannabis, and summarizes studies that have examined the effects of parental exposure to cannabis or delta-9 tetrahydrocannabinol (THC, the main psychoactive component of cannabis) on the epigenetic profile of the gametes and behavior of offspring. These studies have demonstrated significant changes to the sperm DNA methylome following cannabis use in humans, and THC exposure in rats. Furthermore, the use of rodent models has shown methylation and behavioral changes in rats born to fathers exposed to THC or synthetic cannabinoids, or to parents who were both exposed to THC. These data substantiate an urgent need for additional studies assessing the effects of cannabis exposure on childhood health and development. This is especially true given the current growing state of cannabis use in the USA.

dc.identifier

dvaa002

dc.identifier.issn

2058-5888

dc.identifier.issn

2058-5888

dc.identifier.uri

https://hdl.handle.net/10161/20347

dc.language

eng

dc.publisher

Oxford University Press (OUP)

dc.relation.ispartof

Environmental epigenetics

dc.relation.isversionof

10.1093/eep/dvaa002

dc.subject

DNA methylation

dc.subject

cannabis

dc.subject

heritability

dc.subject

marijuana

dc.subject

paternal effects

dc.subject

preconception

dc.subject

sperm

dc.title

Cannabis use and the sperm epigenome: a budding concern?

dc.type

Journal article

duke.contributor.orcid

Murphy, Susan K|0000-0001-8298-7272

pubs.begin-page

dvaa002

pubs.issue

1

pubs.organisational-group

School of Medicine

pubs.organisational-group

Environmental Sciences and Policy

pubs.organisational-group

Duke Cancer Institute

pubs.organisational-group

Pathology

pubs.organisational-group

Duke

pubs.organisational-group

Nicholas School of the Environment

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Clinical Science Departments

pubs.publication-status

Published

pubs.volume

6

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Cannabis use and the sperm epigenome a budding concern.pdf
Size:
216.27 KB
Format:
Adobe Portable Document Format
Description:
Published version