Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model.

dc.contributor.author

Allen, Kyle D

dc.contributor.author

Adams, Samuel B

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Setton, Lori A

dc.coverage.spatial

United States

dc.date.accessioned

2011-04-15T16:46:37Z

dc.date.issued

2010-02

dc.description.abstract

Osteoarthritis (OA) is a degenerative joint disease that can result in joint pain, loss of joint function, and deleterious effects on activity levels and lifestyle habits. Current therapies for OA are largely aimed at symptomatic relief and may have limited effects on the underlying cascade of joint degradation. Local drug delivery strategies may provide for the development of more successful OA treatment outcomes that have potential to reduce local joint inflammation, reduce joint destruction, offer pain relief, and restore patient activity levels and joint function. As increasing interest turns toward intra-articular drug delivery routes, parallel interest has emerged in evaluating drug biodistribution, safety, and efficacy in preclinical models. Rodent models provide major advantages for the development of drug delivery strategies, chiefly because of lower cost, successful replication of human OA-like characteristics, rapid disease development, and small joint volumes that enable use of lower total drug amounts during protocol development. These models, however, also offer the potential to investigate the therapeutic effects of local drug therapy on animal behavior, including pain sensitivity thresholds and locomotion characteristics. Herein, we describe a translational paradigm for the evaluation of an intra-articular drug delivery strategy in a rat OA model. This model, a rat interleukin-1beta overexpression model, offers the ability to evaluate anti-interleukin-1 therapeutics for drug biodistribution, activity, and safety as well as the therapeutic relief of disease symptoms. Once the action against interleukin-1 is confirmed in vivo, the newly developed anti-inflammatory drug can be evaluated for evidence of disease-modifying effects in more complex preclinical models.

dc.description.version

Version of Record

dc.identifier

https://www.ncbi.nlm.nih.gov/pubmed/19943805

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1937-3376

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https://hdl.handle.net/10161/3360

dc.language

eng

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en_US

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Mary Ann Liebert Inc

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Tissue Eng Part B Rev

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10.1089/ten.teb.2009.0447

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Tissue Engineering Part B-Reviews

dc.subject

Animals

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Disease Models, Animal

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Drug Delivery Systems

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Evaluation Studies as Topic

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Injections, Intra-Articular

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Osteoarthritis

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Rats

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Tissue Distribution

dc.title

Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model.

dc.type

Journal article

duke.contributor.orcid

Adams, Samuel B|0000-0003-1020-1167

duke.date.pubdate

2010-2-0

duke.description.issue

1

duke.description.volume

16

pubs.author-url

https://www.ncbi.nlm.nih.gov/pubmed/19943805

pubs.begin-page

81

pubs.end-page

92

pubs.issue

1

pubs.organisational-group

Biomedical Engineering

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Clinical Science Departments

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Duke

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Duke Institute for Brain Sciences

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Institutes and Provost's Academic Units

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Orthopaedics

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Pratt School of Engineering

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School of Medicine

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University Institutes and Centers

pubs.publication-status

Published

pubs.volume

16

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