NUAK2 is a therapeutically tractable regulator of RNA splicing and tumor progression in neuroendocrine prostate cancer
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2025-11-13
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Mehraj, Umar, Uran Maimekov, Shaista Manzoor, Emily Cordova, Manasiben Patel, Ikeer Y Mancera-Ortiz, Stefanie Howell, Zachary W Davis-Gilbert, et al. (2025). NUAK2 is a therapeutically tractable regulator of RNA splicing and tumor progression in neuroendocrine prostate cancer. Preprint version: 10.1101/2025.11.12.687734 Retrieved from https://hdl.handle.net/10161/33797.
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Scholars@Duke
Ming Chen
Our laboratory is interested in understanding the molecular and genetic events underlying cancer progression and metastasis. The focus of our work is a series of genetically engineered mouse models that faithfully recapitulate human disease. Using a combination of mouse genetics, omics technologies, cross-species analyses and in vitro approaches, we aim to identify cancer cell–intrinsic and –extrinsic mechanisms driving metastatic cancer progression, with a long–term goal of developing new therapeutic strategies for preventing and treating metastatic disease.
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