Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance

Clinical Anesthesia
My principal clinical interest is the use of peripheral nerve blocks in primarily orthopedic joint replacement procedures. I am a member of the Regional Division with responsibilities to spine, trauma & plastic surgery.

I was the co-director of the Carolina Cadaver Course, which was run annually in conjunction with Wake Forest University School of Medicine. I have been involved in teaching the use of ultrasound for the placement of peripheral nerve blocks and have lectured on several national courses.

Human Pharmacology & Physiology Lab (HPPL)
I am the Director of the HPPL which is the the Department of Anesthesiology's clinical research lab designed to conduct studies in healthy volunteers. It is designed to collect comprehensive physiological data in a manner similar to the Operating Room (OR), using both non-invasive and invasive techniques. The key areas of interest are:

• Early human clinical drug trials (Phase 1 & 2) of drugs related to anesthesia
• Conduct of clinical equipment validation studies prior to FDA approval

Dr. Michael W. Manning, MD, Ph.D., is an Associate Professor at Duke University Medical Center, within the Divisions of Cardiothoracic and General, Vascular, and Transplant anesthesia. He serves as the director of Enhanced Recovery after Surgery programs and the director of research for the Perioperative Medicine Fellowship at Duke. His clinical practice focuses on high-risk cardiac surgery, Heart, Lung, and Liver transplantation.

Dr. Manning earned a Ph.D. in cardiovascular physiology from the University of Kentucky, where he studied the role of Angiotensin II-mediated inflammation in the development of abdominal aortic aneurysms. After graduate school, Dr. Manning remained at the University of Kentucky, earning his MD degree. He completed a year of general surgery residency before switching to anesthesia. Following residency, Dr. 
Manning continued his clinical training at Duke University with a one-year clinical fellowship in Adult Cardiothoracic Anesthesiology and a 2-year research fellowship. He joined the Duke faculty in 2014. 

His current research interests are ERAS centered, specifically in the role of opioid-free anesthesia and goal-directed fluid therapy in cardiac surgery on renal outcomes.

Clinical and research interests are Enhanced Recovery and Perioperative Medicine; with particular interests in fluid management, and perioperative optimization of the high-risk non-cardiac surgery patient.