Clinical and radiographic presentation and treatment of patients with cervical deformity secondary to thoracolumbar proximal junctional kyphosis are distinct despite achieving similar outcomes: Analysis of 123 prospective CD cases.

dc.contributor.author

Passias, Peter G

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Horn, Samantha R

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Poorman, Gregory W

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Daniels, Alan H

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Hamilton, D Kojo

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Kim, Han Jo

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Diebo, Bassel G

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Steinmetz, Leah

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Bortz, Cole A

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Segreto, Frank A

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Sciubba, Daniel M

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Smith, Justin S

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Neuman, Brian J

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Shaffrey, Christopher I

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Lafage, Renaud

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Lafage, Virginie

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Ames, Christopher

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Hart, Robert

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Mundis, Gregory

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Eastlack, Robert K

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Schwab, Frank J

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International Spine Study Group (ISSG)

dc.date.accessioned

2023-06-20T16:26:58Z

dc.date.available

2023-06-20T16:26:58Z

dc.date.issued

2018-10

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2023-06-20T16:26:58Z

dc.description.abstract

CD development secondary to PJK was recently documented in adult spinal deformity patients after surgical correction for thoracolumbar ASD. This study analyzes surgical management of patients with CD secondary to proximal junctional kyphosis (PJK) versus patients with primary CD. Retrospective review of multicenter cervical deformity (CD) database. CD defined as at least one of the following: C2-C7 coronal Cobb > 10°, cervical lordosis (CL) > 10°, cervical sagittal vertical axis (cSVA) > 4cm, CBVA > 25°. Patients were grouped into those with PJK (UIV +2 < -10°) prior to cervical surgery versus who don't (Non-PJK). Independent t-tests and chi-squared tests compared radiographic, clinical, and surgical metrics between PJK and non-PJK groups. Of 123 eligible CD patients, 26(21.1%) had radiographic PJK prior to cervical surgery. PJK patients had significantly greater T2-T12 thoracic kyphosis (-58.8° vs -45.0°, p = 0.002), cSVA (49.1 mm vs 38.9 mm, p = 0.020), T1 Slope (42.6° vs 28.4°, p < 0.001), TS-CL (44.1° vs 35.6°, p = 0.048), C2-T3 SVA (98.8 mm vs 75.8 mm, p = 0.015), C2 Slope (45.4° vs 36.0°, p = 0.043), and CTPA (6.4° vs 4.6°, p = 0.005). Comparing their surgeries, the PJK group had significantly more levels fused (10.7 vs 7.4, p = 0.01). There was significantly greater blood loss in PJK patients (1158 ± 1063vs 738 ± 793 cc, p = 0.028); operative time, surgical approach, and BMP-2 use were similar (all p > 0.05). PJK patients experienced higher rates of complications 30 and 90 days post-operatively (23.1% vs. 5.2%, p = 0.004; 30.8% vs. 19.6%, p = 0.026), and more instrumentation failure 30 days postoperatively (7.8% vs. 1.0%, p = 0.004). Patients with cervical deformity secondary to PJK had worse baseline CD, despite no differences in HRQL or demographics. Surgical correction of CD associated with PJK required more invasive surgery and had higher complication rates than non-PJK patients, despite achieving similar clinical outcomes.

dc.identifier

S0967-5868(18)30583-6

dc.identifier.issn

0967-5868

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1532-2653

dc.identifier.uri

https://hdl.handle.net/10161/28248

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

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10.1016/j.jocn.2018.06.040

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International Spine Study Group (ISSG)

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Cervical Vertebrae

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Thoracic Vertebrae

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Humans

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Kyphosis

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Postoperative Complications

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Radiography

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Neurosurgical Procedures

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Adult

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Middle Aged

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Female

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Male

dc.title

Clinical and radiographic presentation and treatment of patients with cervical deformity secondary to thoracolumbar proximal junctional kyphosis are distinct despite achieving similar outcomes: Analysis of 123 prospective CD cases.

dc.type

Journal article

duke.contributor.orcid

Shaffrey, Christopher I|0000-0001-9760-8386

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121

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126

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Duke

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School of Medicine

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Clinical Science Departments

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Orthopaedic Surgery

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Neurosurgery

pubs.publication-status

Published

pubs.volume

56

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