Perioperative Management of Bleeding and Transfusion for Lung Transplantation.

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Perioperative allogeneic blood product transfusion is common in lung transplantation and has various implications on the short- and long-term outcomes of lung recipients. This review summarizes the effect of transfusion on outcomes including primary graft dysfunction, chronic lung allograft dysfunction, and all-cause mortality. We outline known risk factors for increased transfusion requirement in lung transplantation and present current evidence regarding the effect of hemostatic agents including antifibrinolytics, recombinant factor VII, and prothrombin complex concentrates. Finally, we highlight the roles of point-of-care coagulation testing and goal-directed transfusion strategies in reducing transfusion requirements in lung transplantation.





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Pena, Joseph J, Brandi A Bottiger and Andrea N Miltiades (2019). Perioperative Management of Bleeding and Transfusion for Lung Transplantation. Seminars in cardiothoracic and vascular anesthesia. p. 1089253219869030. 10.1177/1089253219869030 Retrieved from

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Brandi Anne Bottiger

Associate Professor of Anesthesiology

I have been a member of the Cardiothoracic Anesthesiology division and Department of anesthesiology for >10 years, caring for cardiac and thoracic surgical patients. I am the current cardiothoracic anesthesiology fellowship director of 14 fellows (  My academic interests are in education, CTA content development, and specific interests in outcomes improvement after lung transplantation. Additionally, I have greatly appreciated my leadership role and ability to engage with the Duke Transplant Center.

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