Reliable genotypic tropism tests for the major HIV-1 subtypes.
| dc.contributor.author | Cashin, Kieran | |
| dc.contributor.author | Gray, Lachlan R | |
| dc.contributor.author | Harvey, Katherine L | |
| dc.contributor.author | Perez-Bercoff, Danielle | |
| dc.contributor.author | Lee, Guinevere Q | |
| dc.contributor.author | Sterjovski, Jasminka | |
| dc.contributor.author | Roche, Michael | |
| dc.contributor.author | Demarest, James F | |
| dc.contributor.author | Drummond, Fraser | |
| dc.contributor.author | Harrigan, P Richard | |
| dc.contributor.author | Churchill, Melissa J | |
| dc.contributor.author | Gorry, Paul R | |
| dc.date.accessioned | 2022-03-09T18:03:05Z | |
| dc.date.available | 2022-03-09T18:03:05Z | |
| dc.date.issued | 2015-02-25 | |
| dc.date.updated | 2022-03-09T18:03:04Z | |
| dc.description.abstract | Over the past decade antiretroviral drugs have dramatically improved the prognosis for HIV-1 infected individuals, yet achieving better access to vulnerable populations remains a challenge. The principal obstacle to the CCR5-antagonist, maraviroc, from being more widely used in anti-HIV-1 therapy regimens is that the pre-treatment genotypic "tropism tests" to determine virus susceptibility to maraviroc have been developed primarily for HIV-1 subtype B strains, which account for only 10% of infections worldwide. We therefore developed PhenoSeq, a suite of HIV-1 genotypic tropism assays that are highly sensitive and specific for establishing the tropism of HIV-1 subtypes A, B, C, D and circulating recombinant forms of subtypes AE and AG, which together account for 95% of HIV-1 infections worldwide. The PhenoSeq platform will inform the appropriate use of maraviroc and future CCR5 blocking drugs in regions of the world where non-B HIV-1 predominates, which are burdened the most by the HIV-1 pandemic. | |
| dc.identifier | srep08543 | |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Springer Science and Business Media LLC | |
| dc.relation.ispartof | Scientific reports | |
| dc.relation.isversionof | 10.1038/srep08543 | |
| dc.subject | Humans | |
| dc.subject | HIV-1 | |
| dc.subject | HIV Infections | |
| dc.subject | Cyclohexanes | |
| dc.subject | Triazoles | |
| dc.subject | Peptide Fragments | |
| dc.subject | Receptors, CCR5 | |
| dc.subject | HIV Envelope Protein gp120 | |
| dc.subject | Computational Biology | |
| dc.subject | Amino Acid Sequence | |
| dc.subject | Genotype | |
| dc.subject | Phenotype | |
| dc.subject | Mutation | |
| dc.subject | Algorithms | |
| dc.subject | Viral Tropism | |
| dc.subject | CCR5 Receptor Antagonists | |
| dc.subject | Maraviroc | |
| dc.title | Reliable genotypic tropism tests for the major HIV-1 subtypes. | |
| dc.type | Journal article | |
| pubs.begin-page | 8543 | |
| pubs.issue | 1 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Immunology | |
| pubs.publication-status | Published | |
| pubs.volume | 5 |
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