Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.

dc.contributor.author

Wong, Zhee S

dc.contributor.author

Borrelli, Sarah L Sokol

dc.contributor.author

Coyne, Carolyn C

dc.contributor.author

Boyle, Jon P

dc.date.accessioned

2021-04-16T19:52:22Z

dc.date.available

2021-04-16T19:52:22Z

dc.date.issued

2020-05-11

dc.date.updated

2021-04-16T19:52:22Z

dc.description.abstract

Toxoplasma gondii is remarkably unique in its ability to successfully infect vertebrate hosts from multiple phyla and can successfully infect most cells within these organisms. The infection outcome in each of these species is determined by the complex interaction between parasite and host genotype. As techniques to quantify global changes in cell function become more readily available and precise, new data are coming to light about how (i) different host cell types respond to parasitic infection and (ii) different parasite species impact the host. Here we focus on recent studies comparing the response to intracellular parasitism by different cell types and insights into understanding host-parasite interactions from comparative studies on T. gondii and its close extant relatives.

dc.identifier

S0020-7519(20)30096-5

dc.identifier.issn

0020-7519

dc.identifier.issn

1879-0135

dc.identifier.uri

https://hdl.handle.net/10161/22576

dc.language

eng

dc.relation.ispartof

International journal for parasitology

dc.relation.isversionof

10.1016/j.ijpara.2020.05.001

dc.subject

Cell Line

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Animals

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Mammals

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Humans

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Apicomplexa

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Neospora

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Toxoplasma

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Coccidiosis

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Toxoplasmosis

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Protein-Serine-Threonine Kinases

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Chemokines

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Virulence

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Immunity

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Gene Expression

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Tumor Suppressor Protein p53

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Host-Parasite Interactions

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Interferon-gamma

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Biological Evolution

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Host Specificity

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Transcriptome

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THP-1 Cells

dc.title

Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.

dc.type

Journal article

duke.contributor.orcid

Coyne, Carolyn C|0000-0002-1884-6309

pubs.begin-page

423

pubs.end-page

431

pubs.issue

5

pubs.organisational-group

School of Medicine

pubs.organisational-group

Molecular Genetics and Microbiology

pubs.organisational-group

Duke

pubs.organisational-group

Basic Science Departments

pubs.publication-status

Published

pubs.volume

50

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