Advances in understanding palmitic acid metabolism and health risks.
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2023-09
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Guyton, John R, Michelle Ponder and Carol F Kirkpatrick (2023). Advances in understanding palmitic acid metabolism and health risks. Journal of clinical lipidology, 17(5). pp. 571–572. 10.1016/j.jacl.2023.09.011 Retrieved from https://hdl.handle.net/10161/34867.
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John Richard Guyton
Current research efforts focus on the role of niacin in clinical lipid practice. Despite the ending of a large clinical trial due to lack of benefit, niacin remains the second best lipid-modifying drug after statins. Why this trial did not replicate earlier success with niacin is a matter of great interest. Counterregulatory hormone responses may provide the answer. Another research focus is weight loss counseling in the busy clinic setting. Low glycemic dietary advice achieved average long-term weight loss of 3% (beyond 1 year) in a recently published study. One in four patients had long-term weight loss greater than 6%.
Dr. Guyton is recognized nationally as an expert in clinical management of lipid disorders and a leader in postgraduate education in this area. Both nationally and internationally, Dr. Guyton is known for his earlier work on lipid deposition in the arterial wall.
Key words: atherosclerosis, lipoproteins, statins, niacin, triglycerides, low density lipoproteins, high density lipoproteins
Michelle Meriweather Ponder
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