It Is as It Was: MDS-UPDRS Part III Scores Cannot Be Combined with Other Parts to Give a Valid Sum.
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2022-12
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Abstract
Background
Original clinimetric analyses by the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) developers did not confirm the validity of summing the scores of its parts. Recent studies used the summed score of Part III and other parts as efficacy outcomes.Objective
The aim of this study was to establish whether summing scores of MDS-UPDRS parts can be recommended.Methods
Using 7466 full MDS-UPDRS scores, we applied two-step factor analysis as in the original article to reassess the validity analysis with the threshold criterion set at comparative fit index ≥0.9.Results
All comparative fit indexes of any combination including Part III were lower than 0.90.Conclusions
Summing Part III MDS-UPDRS scores with other parts is not clinimetrically sound. The MDS-UPDRS is a validated four-part scale with corresponding individual part scores and needs to be used within the limits originally presented. © 2022 International Parkinson and Movement Disorder Society.Type
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Goetz, Christopher G, Dongrak Choi, Yuanyuan Guo, Glenn T Stebbins, Tiago A Mestre and Sheng Luo (2022). It Is as It Was: MDS-UPDRS Part III Scores Cannot Be Combined with Other Parts to Give a Valid Sum. Movement disorders : official journal of the Movement Disorder Society. 10.1002/mds.29279 Retrieved from https://hdl.handle.net/10161/26668.
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