Challenges in measuring the effects of pharmacological interventions on cognitive and adaptive functioning in individuals with Down syndrome: A systematic review.
| dc.contributor.author | Keeling, Lori A | |
| dc.contributor.author | Spiridigliozzi, Gail A | |
| dc.contributor.author | Hart, Sarah J | |
| dc.contributor.author | Baker, Jane A | |
| dc.contributor.author | Jones, Harrison N | |
| dc.contributor.author | Kishnani, Priya S | |
| dc.date.accessioned | 2023-05-02T13:21:59Z | |
| dc.date.available | 2023-05-02T13:21:59Z | |
| dc.date.issued | 2017-11 | |
| dc.date.updated | 2023-05-02T13:21:59Z | |
| dc.description.abstract | We systematically reviewed the measures used in pharmaceutical trials in children/adults with Down syndrome without dementia. Our purpose was to identify developmentally appropriate outcome measures capable of detecting changes in cognitive and adaptive functioning in this population. Eleven studies were included and used diverse outcome measures across the domains of language, memory, attention, behavior, and executive/adaptive functioning. Our results highlight the challenges in selecting measures capable of capturing improvements in pharmaceutical trials in individuals with DS. We offer suggestions to enhance future research, including: conducting studies with larger samples of participants with a range of developmental abilities; modifying existing/developing novel outcome measures; incorporating advances from related areas and DS observational studies; and considering alternative analytic techniques to characterize treatment effects. | |
| dc.identifier.issn | 1552-4825 | |
| dc.identifier.issn | 1552-4833 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Wiley | |
| dc.relation.ispartof | American journal of medical genetics. Part A | |
| dc.relation.isversionof | 10.1002/ajmg.a.38416 | |
| dc.subject | Humans | |
| dc.subject | Dementia | |
| dc.subject | Down Syndrome | |
| dc.subject | Cognition | |
| dc.subject | Memory | |
| dc.subject | Attention | |
| dc.subject | Cognitive Dysfunction | |
| dc.title | Challenges in measuring the effects of pharmacological interventions on cognitive and adaptive functioning in individuals with Down syndrome: A systematic review. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Jones, Harrison N|0000-0002-4171-980X | |
| duke.contributor.orcid | Kishnani, Priya S|0000-0001-8251-909X | |
| pubs.begin-page | 3058 | |
| pubs.end-page | 3066 | |
| pubs.issue | 11 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Molecular Genetics and Microbiology | |
| pubs.organisational-group | Pediatrics | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences | |
| pubs.organisational-group | Pediatrics, Medical Genetics | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Psychiatry, Child & Family Mental Health & Community Psychiatry | |
| pubs.organisational-group | Initiatives | |
| pubs.organisational-group | Duke Innovation & Entrepreneurship | |
| pubs.organisational-group | Head and Neck Surgery & Communication Sciences | |
| pubs.publication-status | Published | |
| pubs.volume | 173 |
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