Telomerase ribonucleoprotein and genome integrity-An emerging connection in protozoan parasites.

dc.contributor.author

Davis, Justin Alexander

dc.contributor.author

Chakrabarti, Kausik

dc.date.accessioned

2024-08-20T19:21:11Z

dc.date.available

2024-08-20T19:21:11Z

dc.date.issued

2022-09

dc.description.abstract

Telomerase has an established role in telomere maintenance in eukaryotes. However, recent studies have begun to implicate telomerase in cellular roles beyond telomere maintenance. Specifically, evidence is emerging of cross-talks between telomerase mediated telomere homeostasis and DNA repair pathways. Telomere shortening due to the end replication problem is a constant threat to genome integrity in eukaryotic cells. This poses a particular problem in unicellular parasitic protists because their major virulence genes are located at the subtelomeric loci. Although telomerase is the major regulator of telomere lengthening in eukaryotes, it is less studied in the ancient eukaryotes, including clinically important human pathogens. Recent research is highlighting interplay between telomerase and the DNA damage response in human parasites. The importance of this interplay in pathogen virulence is only beginning to be illuminated, including the potential to highlight novel developmental regulation of telomerase in parasites who transition between multiple developmental stages throughout their life cycle. In this review, we will discuss the telomerase ribonucleoprotein enzyme and DNA repair pathways with emerging views in human parasites to give a broader perspective of the possible connection of telomere, telomerase, and DNA repair pathways across eukaryotic lineages and highlight their potential role in pathogen virulence. This article is categorized under: RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems RNA Evolution and Genomics > RNA and Ribonucleoprotein Evolution RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications.

dc.identifier.issn

1757-7004

dc.identifier.issn

1757-7012

dc.identifier.uri

https://hdl.handle.net/10161/31421

dc.language

eng

dc.publisher

Wiley

dc.relation.ispartof

Wiley interdisciplinary reviews. RNA

dc.relation.isversionof

10.1002/wrna.1710

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.subject

Telomere

dc.subject

Animals

dc.subject

Humans

dc.subject

Parasites

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Telomerase

dc.subject

Ribonucleoproteins

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RNA

dc.subject

Eukaryota

dc.title

Telomerase ribonucleoprotein and genome integrity-An emerging connection in protozoan parasites.

dc.type

Journal article

pubs.begin-page

e1710

pubs.issue

5

pubs.organisational-group

Duke

pubs.organisational-group

Trinity College of Arts & Sciences

pubs.organisational-group

Staff

pubs.organisational-group

Chemistry

pubs.publication-status

Published

pubs.volume

13

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