Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.
dc.contributor.author | Ward-Caviness, Cavin K | |
dc.contributor.author | Russell, Armistead G | |
dc.contributor.author | Weaver, Anne M | |
dc.contributor.author | Slawsky, Erik | |
dc.contributor.author | Dhingra, Radhika | |
dc.contributor.author | Kwee, Lydia Coulter | |
dc.contributor.author | Jiang, Rong | |
dc.contributor.author | Neas, Lucas M | |
dc.contributor.author | Diaz-Sanchez, David | |
dc.contributor.author | Devlin, Robert B | |
dc.contributor.author | Cascio, Wayne E | |
dc.contributor.author | Olden, Kenneth | |
dc.contributor.author | Hauser, Elizabeth R | |
dc.contributor.author | Shah, Svati H | |
dc.contributor.author | Kraus, William E | |
dc.date.accessioned | 2023-08-01T14:05:13Z | |
dc.date.available | 2023-08-01T14:05:13Z | |
dc.date.issued | 2020-12 | |
dc.date.updated | 2023-08-01T14:05:11Z | |
dc.description.abstract | BackgroundAccelerated epigenetic age has been proposed as a biomarker of increased aging, which may indicate disruptions in cellular and organ system homeostasis and thus contribute to sensitivity to environmental exposures.MethodsUsing 497 participants from the CATHGEN cohort, we evaluated whether accelerated epigenetic aging increases cardiovascular sensitivity to traffic-related air pollution (TRAP) exposure. We used residential proximity to major roadways and source apportioned air pollution models as measures of TRAP exposure, and chose peripheral arterial disease (PAD) and blood pressure as outcomes based on previous associations with TRAP. We used Horvath epigenetic age acceleration (AAD) and phenotypic age acceleration (PhenoAAD) as measures of age acceleration, and adjusted all models for chronological age, race, sex, smoking, and socioeconomic status.ResultsWe observed significant interactions between TRAP and both AAD and PhenoAAD. Interactions indicated that increased epigenetic age acceleration elevated associations between proximity to roadways and PAD. Interactions were also observed between AAD and gasoline and diesel source apportioned PM2.5.ConclusionEpigenetic age acceleration may be a biomarker of sensitivity to air pollution, particularly for TRAP in urban cohorts. This presents a novel means by which to understand sensitivity to air pollution and provides a molecular measure of environmental sensitivity. | |
dc.identifier | 202341 | |
dc.identifier.issn | 1945-4589 | |
dc.identifier.issn | 1945-4589 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Impact Journals, LLC | |
dc.relation.ispartof | Aging | |
dc.relation.isversionof | 10.18632/aging.202341 | |
dc.subject | Humans | |
dc.subject | Genetic Markers | |
dc.subject | Risk Assessment | |
dc.subject | Vehicle Emissions | |
dc.subject | Environmental Exposure | |
dc.subject | Environmental Monitoring | |
dc.subject | Age Factors | |
dc.subject | Residence Characteristics | |
dc.subject | DNA Methylation | |
dc.subject | Epigenesis, Genetic | |
dc.subject | Aging | |
dc.subject | Blood Pressure | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Urban Health | |
dc.subject | North Carolina | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Peripheral Arterial Disease | |
dc.subject | Traffic-Related Pollution | |
dc.subject | Heart Disease Risk Factors | |
dc.title | Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution. | |
dc.type | Journal article | |
duke.contributor.orcid | Kwee, Lydia Coulter|0000-0002-6997-8571 | |
duke.contributor.orcid | Hauser, Elizabeth R|0000-0003-0367-9189 | |
duke.contributor.orcid | Shah, Svati H|0000-0002-3495-2830 | |
duke.contributor.orcid | Kraus, William E|0000-0003-1930-9684 | |
pubs.begin-page | 24141 | |
pubs.end-page | 24155 | |
pubs.issue | 23 | |
pubs.organisational-group | Duke | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | School of Nursing | |
pubs.organisational-group | Staff | |
pubs.organisational-group | Nursing | |
pubs.organisational-group | Basic Science Departments | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Biostatistics & Bioinformatics | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Psychiatry & Behavioral Sciences | |
pubs.organisational-group | Medicine, Cardiology | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Duke Clinical Research Institute | |
pubs.organisational-group | Duke Molecular Physiology Institute | |
pubs.organisational-group | Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences | |
pubs.publication-status | Published | |
pubs.volume | 12 |
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