Prescription pain reliever abuse and dependence among adolescents: a nationally representative study.

dc.contributor.author

Wu, Li-Tzy

dc.contributor.author

Ringwalt, Christopher L

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Mannelli, Paolo

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Patkar, Ashwin A

dc.date.accessioned

2020-02-03T06:06:29Z

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2020-02-03T06:06:29Z

dc.date.issued

2008-09

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2020-02-03T06:06:28Z

dc.description.abstract

We examined the prevalence, patterns, and correlates of adolescents' abuse, subthreshold dependence ("diagnostic orphans"), and dependence on prescription pain relievers (PPRs) such as opioids in a representative national sample (N = 36,992).Data were from the 2005-2006 National Surveys of Drug Use and Health. DSM-IV criteria for abuse and dependence were examined.Of all adolescents ages 12 to 17, 7% (n = 2,675) reported nonprescribed PPR use in the past year, and 1% (n = 400) met criteria for past-year PPR abuse or dependence. Among the 2,675 adolescents who reported nonprescribed PPR use, more than one in three reported symptoms of abuse or dependence: 7% abuse, 20% subthreshold dependence, and 9% dependence. Regular PPR use, major depressive episodes, and alcohol use disorders were associated with each diagnostic category. Compared with asymptomatic nonprescribed PPR users, increased odds of abuse were noted among nonstudents (adjusted odds ratio [AOR] 2.6), users of mental health services (AOR 1.8), and those reporting poor or fair health (AOR 2.4); and increased odds of dependence were observed among females (AOR 1.6), those who were involved in selling illicit drugs (AOR 1.7), and users of multiple drugs (AOR 2.9). Subthreshold dependent users resembled dependent users in major depressive episodes (AOR 1.5), alcohol use disorders (AOR 1.8), and use of multiple drugs (AOR 1.7).Dependence on PPRs can occur without abuse, and subthreshold dependence deserves to be investigated further for consideration in major diagnostic classification systems.

dc.identifier

S0890-8567(08)60078-7

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0890-8567

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1527-5418

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https://hdl.handle.net/10161/20012

dc.language

eng

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Elsevier BV

dc.relation.ispartof

Journal of the American Academy of Child and Adolescent Psychiatry

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10.1097/CHI.0b013e31817eed4d

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Humans

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Alcoholism

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Opioid-Related Disorders

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Analgesics, Opioid

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Street Drugs

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Health Surveys

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Prospective Studies

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Cross-Sectional Studies

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Depressive Disorder, Major

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Comorbidity

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Adolescent

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Child

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United States

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Female

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Male

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Nonprescription Drugs

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Prescription Drugs

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Drug Overdose

dc.title

Prescription pain reliever abuse and dependence among adolescents: a nationally representative study.

dc.type

Journal article

duke.contributor.orcid

Wu, Li-Tzy|0000-0002-5909-2259

duke.contributor.orcid

Mannelli, Paolo|0000-0002-7834-6138

pubs.begin-page

1020

pubs.end-page

1029

pubs.issue

9

pubs.organisational-group

School of Medicine

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Duke

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Center for Child and Family Policy

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Sanford School of Public Policy

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Duke Clinical Research Institute

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Institutes and Centers

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Duke Institute for Brain Sciences

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University Institutes and Centers

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Institutes and Provost's Academic Units

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Psychiatry & Behavioral Sciences, Social and Community Psychiatry

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Psychiatry & Behavioral Sciences

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Clinical Science Departments

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Medicine, General Internal Medicine

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Medicine

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Family Medicine and Community Health, Community Health

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Family Medicine and Community Health

pubs.publication-status

Published

pubs.volume

47

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