Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.
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2009
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Abstract
A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.
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Ehsan Samei
Dr. Ehsan Samei, PhD, DABR, FAAPM, FSPIE, FAIMBE, FIOMP, FACR is a Persian-American medical physicist. He is the Reed and Martha Rice Distinguished Professor of Radiology, and Professor of Medical Physics, Biomedical Engineering, Physics, and Electrical and Computer Engineering at Duke University. He serves as the Chief Imaging Physicist for Duke University Health System, the Director of the Carl E Ravin Advanced Imaging Laboratories and the Center for Virtual Imaging Trials (CVIT), and Co-Director of the Triangle Centers of Excellence in Regulatory Science and Innovation (Triangle CERSI). Certified by the American Board of Radiology, he is recognized as a Distinguished Investigator by the Academy of Radiology Research, awarded Fellow by five professional organizations, and has been the recipient of the Jimmy O. Fenn Lifetime Achievement Award of SEAAPM and the Marie Sklodowska-Curie Award by IOMP. He founded/co-founded the Duke Medical Physics Program, the Duke Imaging Physics Residency Program, the Duke Clinical Imaging Physics Group, the Center for Virtual Imaging Trials, and the Society of Directors of Academic Medical Physics Programs (SDAMPP). He has held senior leadership positions in the AAPM, SPIE, SDAMPP, and RSNA, including serving as president of the SEAAPM (2010-2011), SDAMPP (2011), and AAPM (2023). He is ranked 8th among over 56,000 medical physicists worldwide for his lifetime contribution to medical physics.
Dr. Samei has mentored over 160 trainees (graduate and postgraduate). He has over 1500 scientific publications, including 4 books, over 430 refereed journal papers, over 260 full-length conference articles, over 350 conference presentations, and over 340 invited talks. Citations to his work are reflected in an h-index of 82 and a Weighted Relative Citation Ratio of 759. His laboratory has been supported continuously for over two decades by 50 extramural grants totaling $47 million. Those include a Program Project grant from the NIH in 2021 to establish the National Center for Virtual Imaging Trials (CVIT), and a multi-institutional grant in 2023 from the FDA to establish the Triangle Center of Excellence in Regulatory Science and Innovation (Triangle CERSI), both joining highly selective biomedical research and regulatory science centers nationwide.
On the personal side, Ehsan Samei is a semi-professional musician, leads a chamber ensemble, and has an active interest in common traits and interactions between science, art, and faith. He has led workshops on leadership and leadership development. He has run five marathons (3:17 PR), including the 2013 Boston Marathon, is married to Dr. Maija Samei, a scholar of medieval Chinese literature, and is blessed with four gifted children.
Cristian Tudorel Badea
- Our QIAL lab advances quantitative imaging by designing novel CT systems, reconstruction algorithms, image analysis and applications, with a core strength in preclinical CT.
- Current efforts center on spectral CT (dual-energy and photon-counting) with nanoparticle contrast agents for theranostics, multidimensional CT for challenging applications such as intracranial aneurysm, cardiac, and perfusion imaging, and modern reconstruction and image processing ( including deep learning).
- In parallel, we lead co-clinical cancer imaging work; I served as PI of the U24 Duke Preclinical Research Resources for Quantitative Imaging Biomarkers within the NCI Co-Clinical Imaging Research Program (CIRP).
- We are also building a virtual preclinical photon-counting CT platform for cancer studies to accelerate method development and translation.
Rex Colle Bentley
Outcome-based research on pathology of endometrial carcinoma, including prognostic significance of histologic features of endometrial carcinoma, variants of endometrial carcinoma, definitions of atypia and well-differentiated carcinoma, and collaborative studies of oncogenes and tumor suppressor genes in endometrial carcinoma.
Endometrial pathology, especially as it relates to molecular/genetic alterations in neoplasms.
Ovarian pathology, especially as it relates to molecular and genetic alterations in neoplasms.
Improving accuracy of radiographic screening for breast cancer, by careful patho-radiographic correlation and study of improved imaging techniques (especially ultrasound).
Use of electron microscopy as a diagnostic and research technique.
Objective measures of pathology resident performance.
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