Genomic transformation by mobile genetic elements
Abstract
Genetic information is encoded in DNA, perpetuating generational transmission of species-specific genetic material. However, DNA sequences are constantly written and rewritten, thus promoting evolution and adaptation to occur at both the cellular and organismal levels. This dynamic process can be facilitated by mobile DNA elements that translocate throughout the genome. While transposable elements are a classic example of mobile DNA, my colleagues and I propose that extrachromosomal circular DNA (ecDNA) represents another class of mobile DNA element. This well documented but poorly studied class of genetic element introduces a new layer of genomic dynamism that reengineers genetic programs and shapes host biology.
Type
Department
Description
Provenance
Subjects
Citation
Permalink
Citation
Chung, Oliver Wei (2025). Genomic transformation by mobile genetic elements. Dissertation, Duke University. Retrieved from https://hdl.handle.net/10161/32711.
Collections
Except where otherwise noted, student scholarship that was shared on DukeSpace after 2009 is made available to the public under a Creative Commons Attribution / Non-commercial / No derivatives (CC-BY-NC-ND) license. All rights in student work shared on DukeSpace before 2009 remain with the author and/or their designee, whose permission may be required for reuse.