Three periods of regulatory innovation during vertebrate evolution.
| dc.contributor.author | Lowe, Craig B | |
| dc.contributor.author | Kellis, Manolis | |
| dc.contributor.author | Siepel, Adam | |
| dc.contributor.author | Raney, Brian J | |
| dc.contributor.author | Clamp, Michele | |
| dc.contributor.author | Salama, Sofie R | |
| dc.contributor.author | Kingsley, David M | |
| dc.contributor.author | Lindblad-Toh, Kerstin | |
| dc.contributor.author | Haussler, David | |
| dc.date.accessioned | 2018-09-13T14:16:03Z | |
| dc.date.available | 2018-09-13T14:16:03Z | |
| dc.date.issued | 2011-08 | |
| dc.date.updated | 2018-09-13T14:16:01Z | |
| dc.description.abstract | The gain, loss, and modification of gene regulatory elements may underlie a substantial proportion of phenotypic changes on animal lineages. To investigate the gain of regulatory elements throughout vertebrate evolution, we identified genome-wide sets of putative regulatory regions for five vertebrates, including humans. These putative regulatory regions are conserved nonexonic elements (CNEEs), which are evolutionarily conserved yet do not overlap any coding or noncoding mature transcript. We then inferred the branch on which each CNEE came under selective constraint. Our analysis identified three extended periods in the evolution of gene regulatory elements. Early vertebrate evolution was characterized by regulatory gains near transcription factors and developmental genes, but this trend was replaced by innovations near extracellular signaling genes, and then innovations near posttranslational protein modifiers. | |
| dc.identifier.issn | 0036-8075 | |
| dc.identifier.issn | 1095-9203 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | American Association for the Advancement of Science (AAAS) | |
| dc.relation.ispartof | Science (New York, N.Y.) | |
| dc.relation.isversionof | 10.1126/science.1202702 | |
| dc.subject | Animals | |
| dc.subject | Vertebrates | |
| dc.subject | Smegmamorpha | |
| dc.subject | Oryzias | |
| dc.subject | Cattle | |
| dc.subject | Humans | |
| dc.subject | Mice | |
| dc.subject | Transcription Factors | |
| dc.subject | DNA, Intergenic | |
| dc.subject | Markov Chains | |
| dc.subject | Sequence Alignment | |
| dc.subject | Evolution, Molecular | |
| dc.subject | Phylogeny | |
| dc.subject | Gene Expression Regulation | |
| dc.subject | Protein Processing, Post-Translational | |
| dc.subject | Regulatory Sequences, Nucleic Acid | |
| dc.subject | Conserved Sequence | |
| dc.subject | Genome | |
| dc.subject | Regulatory Elements, Transcriptional | |
| dc.subject | Genes, Developmental | |
| dc.subject | Selection, Genetic | |
| dc.subject | Biological Evolution | |
| dc.title | Three periods of regulatory innovation during vertebrate evolution. | |
| dc.type | Journal article | |
| pubs.begin-page | 1019 | |
| pubs.end-page | 1024 | |
| pubs.issue | 6045 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Molecular Genetics and Microbiology | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.publication-status | Published | |
| pubs.volume | 333 |