Clinical and pathological stage discordance among 433,514 breast cancer patients.
| dc.contributor.author | Plichta, Jennifer K | |
| dc.contributor.author | Thomas, Samantha M | |
| dc.contributor.author | Sergesketter, Amanda R | |
| dc.contributor.author | Greenup, Rachel A | |
| dc.contributor.author | Fayanju, Oluwadamilola M | |
| dc.contributor.author | Rosenberger, Laura H | |
| dc.contributor.author | Tamirisa, Nina | |
| dc.contributor.author | Hyslop, Terry | |
| dc.contributor.author | Hwang, E Shelley | |
| dc.date.accessioned | 2019-12-01T15:05:10Z | |
| dc.date.available | 2019-12-01T15:05:10Z | |
| dc.date.issued | 2019-10 | |
| dc.date.updated | 2019-12-01T15:05:09Z | |
| dc.description.abstract | BACKGROUND:We aim to determine clinical and pathological stage discordance rates and to evaluate factors associated with discordance. METHODS:Adults with clinical stages I-III breast cancer were identified from the National Cancer Data Base. Concordance was defined as cTN = pTN (discordance: cTN≠pTN). Multivariate logistic regression was used to identify factors associated with discordance. RESULTS:Comparing clinical and pathological stage, 23.1% were downstaged and 8.7% were upstaged. After adjustment, factors associated with downstaging (vs concordance) included grade 3 (OR 10.56, vs grade 1) and HER2-negative (OR 3.79). Factors associated with upstaging (vs concordance) were grade 3 (OR 10.56, vs grade 1), HER2-negative (OR 1.25), and lobular histology (OR 2.47, vs ductal). ER-negative status was associated with stage concordance (vs downstaged or upstaged, OR 0.52 and 0.87). CONCLUSIONS:Among breast cancer patients, nearly one-third exhibit clinical-pathological stage discordance. This high likelihood of discordance is important to consider for counseling and treatment planning. | |
| dc.identifier | S0002-9610(19)30099-6 | |
| dc.identifier.issn | 0002-9610 | |
| dc.identifier.issn | 1879-1883 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Elsevier BV | |
| dc.relation.ispartof | American journal of surgery | |
| dc.relation.isversionof | 10.1016/j.amjsurg.2019.07.016 | |
| dc.subject | Breast cancer staging | |
| dc.subject | Clinical stage | |
| dc.subject | Pathological stage | |
| dc.subject | Stage discordance | |
| dc.title | Clinical and pathological stage discordance among 433,514 breast cancer patients. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Plichta, Jennifer K|0000-0002-7411-0558 | |
| duke.contributor.orcid | Thomas, Samantha M|0000-0002-1561-9303 | |
| duke.contributor.orcid | Fayanju, Oluwadamilola M|0000-0002-0876-975X | |
| duke.contributor.orcid | Rosenberger, Laura H|0000-0002-6829-6747 | |
| duke.contributor.orcid | Hwang, E Shelley|0000-0002-8571-1148 | |
| pubs.begin-page | 669 | |
| pubs.end-page | 676 | |
| pubs.issue | 4 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Radiology | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Surgical Oncology | |
| pubs.organisational-group | Surgery | |
| pubs.organisational-group | Population Health Sciences | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Biostatistics & Bioinformatics | |
| pubs.organisational-group | Faculty | |
| pubs.publication-status | Published | |
| pubs.volume | 218 |
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