Defining the Role of Host Cell Chromatin Traps in Chlamydia trachomatis Pathogenesis
Date
2016
Authors
Advisors
Journal Title
Journal ISSN
Volume Title
Repository Usage Stats
views
downloads
Abstract
Chlamydia trachomatis (CT) is the most common bacterial agent of sexually transmitted infection and can cause damaging inflammation of the female reproductive tract. As an obligate intracellular pathogen, CT must exit exhausted host cells in a manner that favors successful dissemination. Epithelial cells infected with CT expel decondensed nuclear chromatin at the conclusion of an infectious cycle, and these ensnare CT particles. Whether these chromatin traps benefit the host or the pathogen is not obvious. The overall goal of this work is to begin discerning between these possibilities by determining how chromatin traps impact CT survival following exit and how traps contribute to CT-induced inflammatory processes.
Type
Department
Description
Provenance
Citation
Permalink
Citation
Baxter, Ryan Michael (2016). Defining the Role of Host Cell Chromatin Traps in Chlamydia trachomatis Pathogenesis. Master's thesis, Duke University. Retrieved from https://hdl.handle.net/10161/12344.
Collections
Except where otherwise noted, student scholarship that was shared on DukeSpace after 2009 is made available to the public under a Creative Commons Attribution / Non-commercial / No derivatives (CC-BY-NC-ND) license. All rights in student work shared on DukeSpace before 2009 remain with the author and/or their designee, whose permission may be required for reuse.