Thermal analysis in a triple-layered skin structure with embedded vasculature, tumor, and gold nanoshells
dc.contributor.author | Orndorff, C | |
dc.contributor.author | Ponomarev, S | |
dc.contributor.author | Dai, W | |
dc.contributor.author | Bejan, A | |
dc.date.accessioned | 2017-08-09T01:57:52Z | |
dc.date.available | 2017-08-09T01:57:52Z | |
dc.date.issued | 2017-08-01 | |
dc.description.abstract | © 2017 Elsevier Ltd Obtaining accurate temperature distributions in living tissue related to hyperthermia skin cancer treatment without using an intruding sensor is a challenge. Here, we report a mathematical model that can accurately determine the temperature distribution in the tumor region and surrounding normal tissue. The model is based on a modified Pennes’ equation for the bioheat transfer in a 3-D triple-layered skin structure embedded with a vascular countercurrent network and a tumor appearing in the subcutaneous region. The vascular network is designed based on the constructal theory of multi-scale tree-shaped heat exchangers. The tumor is injected with gold nanoshells in order to be heated quickly. The proposed model is implemented numerically using a stable finite difference scheme. The method is demonstrated and tested by an example. | |
dc.identifier.issn | 0017-9310 | |
dc.identifier.uri | ||
dc.publisher | Elsevier BV | |
dc.relation.ispartof | International Journal of Heat and Mass Transfer | |
dc.relation.isversionof | 10.1016/j.ijheatmasstransfer.2017.04.024 | |
dc.title | Thermal analysis in a triple-layered skin structure with embedded vasculature, tumor, and gold nanoshells | |
dc.type | Journal article | |
pubs.begin-page | 677 | |
pubs.end-page | 695 | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Mechanical Engineering and Materials Science | |
pubs.organisational-group | Pratt School of Engineering | |
pubs.publication-status | Published | |
pubs.volume | 111 |
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