Thermal analysis in a triple-layered skin structure with embedded vasculature, tumor, and gold nanoshells

dc.contributor.author

Orndorff, C

dc.contributor.author

Ponomarev, S

dc.contributor.author

Dai, W

dc.contributor.author

Bejan, A

dc.date.accessioned

2017-08-09T01:57:52Z

dc.date.available

2017-08-09T01:57:52Z

dc.date.issued

2017-08-01

dc.description.abstract

© 2017 Elsevier Ltd Obtaining accurate temperature distributions in living tissue related to hyperthermia skin cancer treatment without using an intruding sensor is a challenge. Here, we report a mathematical model that can accurately determine the temperature distribution in the tumor region and surrounding normal tissue. The model is based on a modified Pennes’ equation for the bioheat transfer in a 3-D triple-layered skin structure embedded with a vascular countercurrent network and a tumor appearing in the subcutaneous region. The vascular network is designed based on the constructal theory of multi-scale tree-shaped heat exchangers. The tumor is injected with gold nanoshells in order to be heated quickly. The proposed model is implemented numerically using a stable finite difference scheme. The method is demonstrated and tested by an example.

dc.identifier.issn

0017-9310

dc.identifier.uri

https://hdl.handle.net/10161/15195

dc.publisher

Elsevier BV

dc.relation.ispartof

International Journal of Heat and Mass Transfer

dc.relation.isversionof

10.1016/j.ijheatmasstransfer.2017.04.024

dc.title

Thermal analysis in a triple-layered skin structure with embedded vasculature, tumor, and gold nanoshells

dc.type

Journal article

pubs.begin-page

677

pubs.end-page

695

pubs.organisational-group

Duke

pubs.organisational-group

Mechanical Engineering and Materials Science

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Pratt School of Engineering

pubs.publication-status

Published

pubs.volume

111

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