Nivolumab-Induced Autoimmune Encephalitis in Two Patients with Lung Adenocarcinoma.


Immune checkpoint inhibitors have improved patient survival outcomes in a variety of advanced malignancies. However, they can cause a number of immune-related adverse effects (irAEs) through lymphocyte dysregulation. Central nervous system (CNS) irAEs are rare, but as the number of indications for checkpoint inhibitors increases, there has been emergence of CNS immune-mediated disease among cancer patients. Given the relatively recent recognition of checkpoint inhibitor CNS irAEs, there is no standard treatment, and prognosis is variable. Therefore, there is a great need for further study of checkpoint inhibitor-induced CNS irAEs. Here, we present two unique cases of nivolumab-induced autoimmune encephalitis in patients with non-small cell lung cancer and review the available literature.






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Publication Info

Shah, Suma, Anastasie Dunn-Pirio, Matthew Luedke, Joel Morgenlander, Mark Skeen and Christopher Eckstein (2018). Nivolumab-Induced Autoimmune Encephalitis in Two Patients with Lung Adenocarcinoma. Case reports in neurological medicine, 2018. p. 2548528. 10.1155/2018/2548528 Retrieved from

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Suma Shah

Associate Professor of Neurology

Matthew William Luedke

Associate Professor of Neurology

I have diverse research interests and collaborations.  Clinical research interests include epilepsy quality-of-life interventions and therapeutics and acute care neurological issues like post-cardiac arrest management and quality-of-care issues.  I work with the Duke hyperbaric chamber team on clinical neurophysiological monitoring of ketone-related research.  

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