Toward discovery science of human brain function.

dc.contributor.author

Biswal, BB

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Mennes, M

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Zuo, XN

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Gohel, S

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Kelly, C

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Smith, SM

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Beckmann, CF

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Adelstein, JS

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Buckner, RL

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Colcombe, S

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Dogonowski, AM

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Ernst, M

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Fair, D

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Hampson, M

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Hoptman, MJ

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Hyde, JS

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Kiviniemi, VJ

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Kötter, R

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Li, SJ

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Lin, CP

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Lowe, MJ

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Mackay, C

dc.contributor.author

Madden, DJ

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Madsen, KH

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Margulies, DS

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Mayberg, HS

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McMahon, K

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Monk, CS

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Mostofsky, SH

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Nagel, BJ

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Pekar, JJ

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Peltier, SJ

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Petersen, SE

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Riedl, V

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Rombouts, SA

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Rypma, B

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Schlaggar, BL

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Schmidt, S

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Seidler, RD

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Siegle, GJ

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Sorg, C

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Teng, GJ

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Veijola, J

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Villringer, A

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Walter, M

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Wang, L

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Weng, XC

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Whitfield Gabrieli, S

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Williamson, P

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Windischberger, C

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Zang, YF

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Zhang, HY

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Castellanos, FX

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Milham, MP

dc.date.accessioned

2025-04-01T15:37:43Z

dc.date.available

2025-04-01T15:37:43Z

dc.date.issued

2010-03

dc.description.abstract

Although it is being successfully implemented for exploration of the genome, discovery science has eluded the functional neuroimaging community. The core challenge remains the development of common paradigms for interrogating the myriad functional systems in the brain without the constraints of a priori hypotheses. Resting-state functional MRI (R-fMRI) constitutes a candidate approach capable of addressing this challenge. Imaging the brain during rest reveals large-amplitude spontaneous low-frequency (

dc.identifier

0911855107

dc.identifier.issn

1091-6490

dc.identifier.issn

1091-6490

dc.identifier.uri

https://hdl.handle.net/10161/32173

dc.language

English

dc.publisher

Proceedings of the National Academy of Sciences

dc.relation.ispartof

Proceedings of the National Academy of Sciences of the United States of America

dc.relation.isversionof

10.1073/pnas.0911855107

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.subject

Adolescent Adult Age Factors Aged Algorithms Analysis of Variance Brain Brain Mapping Female Humans Magnetic Resonance Imaging Male Middle Aged Neural Pathways Sex Factors Young Adult anatomy & histology anatomy & histology* methods* physiology physiology*

dc.title

Toward discovery science of human brain function.

dc.type

Journal article

duke.contributor.orcid

Madden, DJ|0000-0003-2815-6552

pubs.begin-page

4734

pubs.end-page

4739

pubs.issue

10

pubs.organisational-group

Duke

pubs.organisational-group

School of Medicine

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Trinity College of Arts & Sciences

pubs.organisational-group

Clinical Science Departments

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Psychiatry & Behavioral Sciences

pubs.organisational-group

Psychology & Neuroscience

pubs.organisational-group

University Institutes and Centers

pubs.organisational-group

Duke Institute for Brain Sciences

pubs.organisational-group

Center for Cognitive Neuroscience

pubs.organisational-group

Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences

pubs.organisational-group

Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology

pubs.publication-status

Published

pubs.volume

107

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