Improving Guideline-Directed Medical Therapy for Patients with Heart Failure with Reduced Ejection Fraction: A Review of Implementation Strategies.
| dc.contributor.author | Harrington, Josephine | |
| dc.contributor.author | Rao, Vishal N | |
| dc.contributor.author | Leyva, Monica | |
| dc.contributor.author | Oakes, Megan | |
| dc.contributor.author | Mentz, Robert J | |
| dc.contributor.author | Bosworth, Hayden B | |
| dc.contributor.author | Pagidipati, Neha J | |
| dc.date.accessioned | 2024-01-02T19:44:55Z | |
| dc.date.available | 2024-01-02T19:44:55Z | |
| dc.date.issued | 2023-12 | |
| dc.description.abstract | Despite recent advances in guideline-directed medical therapy (GDMT) for patients with heart failure with reduced ejection fraction (HFrEF), achievement of target GDMT utilization and up-titration to goal doses continue to be modest. In recent years, a number of different interventional approaches to improve GDMT have been published, but many are limited by single-center experiences with small sample sizes. However, strategies including use of multidisciplinary teams, dedicated GDMT titration algorithms, and clinician audit with feedback have shown promise. There remains a critical need for large, rigorous trials to assess the utility of different interventions to improve use and titration of GDMT in HFrEF. Here, we review existing literature in GDMT implementation for HFrEF, and discuss future directions and considerations within the field. | |
| dc.identifier | S1071-9164(23)00924-7 | |
| dc.identifier.issn | 1071-9164 | |
| dc.identifier.issn | 1532-8414 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Elsevier BV | |
| dc.relation.ispartof | Journal of cardiac failure | |
| dc.relation.isversionof | 10.1016/j.cardfail.2023.12.004 | |
| dc.rights.uri | ||
| dc.title | Improving Guideline-Directed Medical Therapy for Patients with Heart Failure with Reduced Ejection Fraction: A Review of Implementation Strategies. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Rao, Vishal N|0000-0003-3545-4267 | |
| duke.contributor.orcid | Mentz, Robert J|0000-0002-3222-1719 | |
| duke.contributor.orcid | Bosworth, Hayden B|0000-0001-6188-9825 | |
| pubs.begin-page | S1071-9164(23)00924-7 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences | |
| pubs.organisational-group | Medicine, General Internal Medicine | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Center for the Study of Aging and Human Development | |
| pubs.organisational-group | Initiatives | |
| pubs.organisational-group | Duke Science & Society | |
| pubs.organisational-group | Population Health Sciences | |
| pubs.organisational-group | Duke Innovation & Entrepreneurship | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences | |
| pubs.organisational-group | Duke - Margolis Center For Health Policy | |
| pubs.publication-status | Published |
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