Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury.

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2019-01

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Abstract

Cardiovascular disease is the leading cause of mortality worldwide. While reperfusion therapy is vital for patient survival post-heart attack, it also causes further tissue injury, known as myocardial ischemia/reperfusion (I/R) injury in clinical practice. Exploring ways to attenuate I/R injury is of clinical interest for improving post-ischemic recovery. A platelet-inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)-modified platelet membrane and cardiac stromal cell-secreted factors to target the heart after I/R injury is introduced. By taking advantage of the natural infarct-homing ability of platelet membrane and the overexpression of PGE2 receptors (EPs) in the pathological cardiac microenvironment after I/R injury, the PINCs can achieve targeted delivery of therapeutic payload to the injured heart. Furthermore, a synergistic treatment efficacy can be achieved by PINC, which combines the paracrine mechanism of cell therapy with the PGE2/EP receptor signaling that is involved in the repair and regeneration of multiple tissues. In a mouse model of myocardial I/R injury, intravenous injection of PINCs results in augmented cardiac function and mitigated heart remodeling, which is accompanied by the increase in cycling cardiomyocytes, activation of endogenous stem/progenitor cells, and promotion of angiogenesis. This approach represents a promising therapeutic delivery platform for treating I/R injury.

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10.1002/adfm.201803567

Publication Info

Su, Teng, Ke Huang, Hong Ma, Hongxia Liang, Phuong-Uyen Dinh, Justin Chen, Deliang Shen, Tyler A Allen, et al. (2019). Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury. Advanced functional materials, 29(4). p. 1803567. 10.1002/adfm.201803567 Retrieved from https://hdl.handle.net/10161/26323.

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Scholars@Duke

Su

Teng Su

Assistant Professor in Medicine
Allen

Tyler Allen

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